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使用孔隙率为50%的多孔钛椎间融合器对三种腰椎后路椎间融合技术进行计算比较。

Computational comparison of three posterior lumbar interbody fusion techniques by using porous titanium interbody cages with 50% porosity.

作者信息

Lee Yung-Heng, Chung Chi-Jen, Wang Chih-Wei, Peng Yao-Te, Chang Chih-Han, Chen Chih-Hsien, Chen Yen-Nien, Li Chun-Ting

机构信息

Department of Orthopaedic, Ministry of Health and Welfare Feng Yuan Hospital, Taichung City, Taiwan.

Department of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung City, Taiwan.

出版信息

Comput Biol Med. 2016 Apr 1;71:35-45. doi: 10.1016/j.compbiomed.2016.01.024. Epub 2016 Feb 3.

Abstract

This study investigated the biomechanical response of porous cages and lumbar spine segments immediately after surgery and after bone fusion, in addition to the long-term effects of various posterior lumbar interbody fusion (PLIF) techniques, by using the finite element method. Lumbar L3-L4 models based on three PLIF techniques (a single cage at the center of the intervertebral space, a single cage half-anterior to the intervertebral space, and two cages bilateral to the intervertebral space) with and without bone ingrowth were used to determine the biomechanical response of porous cages and lumbar segments instrumented with porous titanium cages (cage porosity=50%, pore diameter=1mm). The results indicated that bone fusion enhanced the stability of the lumbar segments with porous cages without any posterior instrumentation and reduced the peak von Mises stress in the cortical bones and porous cages. Two cages placed bilateral to the intervertebral space achieved the highest structural stability in the lumbar segment and lowest von Mises stress in the cages under both bone fusion conditions. Under identical loading (2-Nm), the range of motion in the single cage at the center of the intervertebral space with bone fusion decreased by 11% (from 1.18° to 1.05°) during flexion and by 66.5% (from 4.46° to 1.5°) during extension in the single cage half-anterior to the intervertebral space with bone fusion compared with no-fusion models. Thus, two porous titanium cages with 50% porosity can achieve high stability of a lumbar segment with PLIF. If only one cage is available, placing the cage half-anterior to the intervertebral space is recommended for managing degenerated lumbar segments.

摘要

本研究采用有限元方法,调查了多孔椎间融合器和腰椎节段在手术后及骨融合后的生物力学响应,以及各种后路腰椎椎间融合术(PLIF)技术的长期影响。基于三种PLIF技术(椎间盘间隙中央单个椎间融合器、椎间盘间隙半前方单个椎间融合器以及椎间盘间隙双侧两个椎间融合器)构建了有无骨长入的L3-L4腰椎模型,以确定多孔椎间融合器和采用多孔钛椎间融合器(椎间融合器孔隙率=50%,孔径=1mm)的腰椎节段的生物力学响应。结果表明,骨融合增强了未进行任何后路内固定的多孔椎间融合器腰椎节段的稳定性,并降低了皮质骨和多孔椎间融合器中的von Mises应力峰值。在两种骨融合条件下,椎间盘间隙双侧放置两个椎间融合器可使腰椎节段获得最高的结构稳定性,且椎间融合器中的von Mises应力最低。在相同载荷(2 N·m)下,与未融合模型相比,骨融合时椎间盘间隙中央单个椎间融合器在屈曲时的活动范围减少了11%(从1.18°降至1.05°),在伸展时减少了66.5%(从4.46°降至1.5°);椎间盘间隙半前方单个椎间融合器在骨融合时在屈曲时的活动范围减少了11%(从1.18°降至1.05°),在伸展时减少了66.5%(从4.46°降至1.5°)。因此,两个孔隙率为50%的多孔钛椎间融合器可通过PLIF实现腰椎节段的高稳定性。如果只有一个椎间融合器,建议将其放置在椎间盘间隙半前方以处理退变的腰椎节段。

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