Banik Tarak, Mondal Krishnendu, Mandal Rupali
Department of Pathology, Malda Medical College, West Bengal University of Health Sciences, Malda, West Bengal, India.
Diagn Cytopathol. 2016 Mar;44(3):235-40. doi: 10.1002/dc.23409. Epub 2015 Dec 21.
Primary breast lymphoma (PBL) is an uncommon neoplastic condition. Though HIV-infection is a known risk factor for the development of extranodal lymphomas, mammary involvement is still a rarity. Radiologically, PBL appears as well circumscribed, heteroechoic, noncalcifying mass. Fine-needle aspiration cytology (FNAC) is commonly used to diagnose this neoplasm; however, subcategorization requires immunophenotypic characterization of the neoplastic cells. Herein, we report two cases of PBL, including a HIV-infected lady; in both the cases FNAC expressed features of non-Hodgkin's lymphoma. Finally, immunohistochemistry on cell-block with CD20 diagnosed both the cases as diffuse large B-cell lymphoma (DLBCL).
原发性乳腺淋巴瘤（PBL）是一种罕见的肿瘤性疾病。虽然HIV感染是已知的结外淋巴瘤发生的危险因素，但乳腺受累仍然罕见。在放射学上，PBL表现为边界清晰、回声不均匀、无钙化的肿块。细针穿刺细胞学检查（FNAC）常用于诊断这种肿瘤；然而，亚分类需要对肿瘤细胞进行免疫表型特征分析。在此，我们报告两例PBL病例，其中一例为HIV感染女性；两例FNAC均表现为非霍奇金淋巴瘤的特征。最后，对细胞块进行CD20免疫组化检查，两例均诊断为弥漫性大B细胞淋巴瘤（DLBCL）。
