每秒运行24000次光谱的宽带相干拉曼光谱技术。

Hashimoto Kazuki, Takahashi Megumi, Ideguchi Takuro, Goda Keisuke

Department of Chemistry, University of Tokyo-7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Research Centre for Spectrochemistry, University of Tokyo-7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Sci Rep. 2016 Feb 15;6:21036. doi: 10.1038/srep21036.

We present a Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS) spectroscopy technique that achieves broadband CARS measurements at an ultrahigh scan rate of more than 20,000 spectra/s - more than 20 times higher than that of previous broadband coherent Raman scattering spectroscopy techniques. This is made possible by an integration of a FT-CARS system and a rapid-scanning retro-reflective optical path length scanner. To demonstrate the technique's strength, we use it to perform broadband CARS spectroscopy of the transient mixing dynamics of toluene and benzene in the fingerprint region (200-1500 cm(-1)) with spectral resolution of 10 cm(-1) at a record high scan rate of 24,000 spectra/s. Our rapid-scanning FT-CARS technique holds great promise for studying chemical dynamics and wide-field label-free biomedical imaging.

我们提出了一种傅里叶变换相干反斯托克斯拉曼散射（FT-CARS）光谱技术，该技术能够以超过20000谱/秒的超高扫描速率实现宽带CARS测量，这比以往的宽带相干拉曼散射光谱技术高出20倍以上。这是通过将FT-CARS系统与快速扫描后向反射光程长度扫描仪集成实现的。为了展示该技术的优势，我们利用它在指纹区（200-1500 cm⁻¹）对甲苯和苯的瞬态混合动力学进行宽带CARS光谱分析，光谱分辨率为10 cm⁻¹，扫描速率达到创纪录的24000谱/秒。我们的快速扫描FT-CARS技术在研究化学动力学和宽场无标记生物医学成像方面具有巨大潜力。