双相抑郁症与认知障碍：共同机制与新的治疗途径
Bipolar Depression and Cognitive Impairment: Shared Mechanisms and New Treatment Avenues.
作者信息
Depp Colin A, Dev Sheena, Eyler Lisa T
机构信息
Department of Psychiatry, UC San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Desert-Pacific Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.
Department of Psychiatry, UC San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; SDSU-UCSD Joint Doctoral Program, Clinical Psychology, San Diego, CA, USA.
出版信息
Psychiatr Clin North Am. 2016 Mar;39(1):95-109. doi: 10.1016/j.psc.2015.09.004. Epub 2015 Dec 11.
Abstract
Depression and cognitive impairment are pervasive and highly disabling aspects of bipolar disorder. Although cognitive impairment is partially independent from mood episodes, depressive symptoms may increase the risk of cognitive impairment in bipolar disorder through inflammatory processes as well as health risks such as obesity and sedentary behavior. Novel treatment avenues at the intersection of bipolar depression and cognitive impairment target inflammation directly or indirectly health behaviors such as diet, physical activity, and sleep hygiene.
摘要
抑郁和认知障碍是双相情感障碍普遍存在且极具致残性的方面。尽管认知障碍部分独立于情绪发作，但抑郁症状可能通过炎症过程以及肥胖和久坐行为等健康风险增加双相情感障碍患者认知障碍的风险。双相抑郁与认知障碍交叉领域的新型治疗途径直接或间接针对炎症以及饮食、体育活动和睡眠卫生等健康行为。
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