Nesvåg Ragnar, Knudsen Gun Peggy, Bakken Inger Johanne, Høye Anne, Ystrom Eivind, Surén Pål, Reneflot Anne, Stoltenberg Camilla, Reichborn-Kjennerud Ted
Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, 0403, Oslo, Norway,
Soc Psychiatry Psychiatr Epidemiol. 2015 Aug;50(8):1267-76. doi: 10.1007/s00127-015-1025-2. Epub 2015 Feb 14.
To compare the prevalence and pattern of comorbid substance use disorders (SUD) between patients with schizophrenia, bipolar disorder, and depressive illness.
Data on presence of alcohol use disorder (AUD) and non-alcohol drug use disorder (DUD) were retrieved from the Norwegian Patient Register for individuals born between 1950 and 1989 who in the period 2009-2013 were diagnosed with schizophrenia, bipolar disorder or depressive illness according to the 10th version of the WHO International Classification of Diseases. The prevalence of AUD only, DUD only, or both was compared between men and women across age and diagnostic groups.
The prevalence of SUD was 25.1 % in schizophrenia (AUD: 4.6 %, DUD: 15.6 %, AUD and DUD: 4.9 %), 20.1 % in bipolar disorder (AUD: 8.1 %, DUD: 7.6 %, AUD and DUD: 4.4 %), and 10.9 % in depressive illness (AUD: 4.4 %, DUD: 4.3 %, AUD and DUD: 2.2 %). Middle-aged men with bipolar disorder had the highest prevalence of AUD (19.1 %) and young men with schizophrenia had the highest prevalence of DUD (29.6 %). Of the specific DUDs, all but sedative use disorder were more prevalent in schizophrenia than the other groups. Cannabis and stimulant use disorder was found among 8.8 and 8.9 %, respectively, of the men with schizophrenia.
The alarmingly high prevalence of DUD among young patients with severe mental disorders should encourage preventive efforts to reduce illicit drug use in the adolescent population.
比较精神分裂症、双相情感障碍和抑郁症患者中合并物质使用障碍（SUD）的患病率及模式。
从挪威患者登记处获取1950年至1989年出生的个体的酒精使用障碍（AUD）和非酒精药物使用障碍（DUD）数据，这些个体在2009 - 2013年期间根据世界卫生组织国际疾病分类第10版被诊断为精神分裂症、双相情感障碍或抑郁症。比较不同年龄和诊断组的男性和女性中仅AUD、仅DUD或两者皆有的患病率。
精神分裂症患者中SUD的患病率为25.1%（AUD：4.6%，DUD：15.6%，AUD和DUD：4.9%），双相情感障碍患者中为20.1%（AUD：8.1%，DUD：7.6%，AUD和DUD：4.4%），抑郁症患者中为10.9%（AUD：4.4%，DUD：4.3%，AUD和DUD：2.2%）。中年双相情感障碍男性AUD患病率最高（19.1%），青年精神分裂症男性DUD患病率最高（29.6%）。在特定的DUD中，除镇静剂使用障碍外，精神分裂症患者中其他DUD的患病率均高于其他组。精神分裂症男性中分别有8.8%和8.9%存在大麻和兴奋剂使用障碍。
严重精神障碍青年患者中DUD的高患病率令人担忧，应鼓励开展预防工作以减少青少年人群中的非法药物使用。
