Zhao Shaojing, Cheng Fa, Chen Yu, Wei Yuping
Department of Chemistry, Tianjin University, Tianjin 300072, PR China.
Department of Chemistry, Tianjin University, Tianjin 300072, PR China.
Carbohydr Polym. 2016 May 5;141:68-74. doi: 10.1016/j.carbpol.2015.10.082. Epub 2015 Oct 30.
Due to the extensive application of cationic cellulose in cosmetic, drug delivery and gene therapy, combining the improvement effect of surfactant-cellulose complexes, to investigate the properties of cellulose in aqueous solution is an important topic from both scientific and technical views. In this study, the phase behavior, solution properties and microstructure of Gemini surfactant sodium 5-nonyl-2-(4-(4-nonyl-2-sulfonatophenoxy)butoxy)phenyl sulfite (9-4-9)/cationic cellulose (JR400, the ammonium groups are directly bonded to the hydroxyethyl substituent with a degree substitution of 0.37) mixture was investigated using turbidity, fluorescence spectrophotometer and shear rheology techniques. As a control, the interaction of corresponding monovalent surfactant, sodium 2-ethoxy-5-nonylbenzenesulfonate (9-2) with JR400 in aqueous solution was also studied. Experimental results showed that 9-4-9/JR400 mixture has lower critical aggregation concentration (CAC) and critical micelle concentration (CMC) (about one order of magnitude) than 9-2/JR400 mixture. A low concentration of Gemini surfactant 9-4-9 appeared to induce an obvious micropolarity and viscosity value variation of the mixture, while these effects required a high concentration of corresponding monovalent one. Furthermore, dynamic light scattering (DLS) and transmission electron microscopy (TEM) measurements illuminated the formation and collapse procedure of network structure of the 9-4-9/JR400 mixture, which resulted in the increase and decrease of viscosity. These results suggest that the molecular structure of the surfactant has a great effect on its interaction with cationic cellulose. Moreover, the Gemini surfactant/cationic cellulose mixture may be used as a potencial stimuli-responsive drug delivery vector which not only load hydrophilic drugs, but also deliver hydrophobic substances.
由于阳离子纤维素在化妆品、药物递送和基因治疗中的广泛应用，结合表面活性剂 - 纤维素复合物的改善效果，从科学和技术角度研究纤维素在水溶液中的性质是一个重要课题。在本研究中，使用浊度法、荧光分光光度计和剪切流变学技术研究了双子表面活性剂5 - 壬基 - 2 - (4 - (4 - 壬基 - 2 - 磺酸钠苯氧基)丁氧基)苯基亚硫酸盐（9 - 4 - 9）/阳离子纤维素（JR400，铵基团直接键合到取代度为0.37的羟乙基取代基上）混合物的相行为、溶液性质和微观结构。作为对照，还研究了相应的单价表面活性剂2 - 乙氧基 - 5 - 壬基苯磺酸钠（9 - 2）与JR400在水溶液中的相互作用。实验结果表明，9 - 4 - 9/JR400混合物比9 - 2/JR400混合物具有更低的临界聚集浓度（CAC）和临界胶束浓度（CMC）（约一个数量级）。低浓度的双子表面活性剂9 - 4 - 九似乎会引起混合物明显的微极性和粘度值变化，而这些效应需要高浓度的相应单价表面活性剂。此外，动态光散射（DLS）和透射电子显微镜（TEM）测量揭示了9 - 4 - 9/JR400混合物网络结构的形成和坍塌过程，这导致了粘度的增加和降低。这些结果表明表面活性剂的分子结构对其与阳离子纤维素的相互作用有很大影响。此外，双子表面活性剂/阳离子纤维素混合物可作为一种潜在的刺激响应药物递送载体，它不仅可以负载亲水性药物，还可以递送疏水性物质。
