Weinberg Anna, Meyer Alexandria, Hale-Rude Emily, Perlman Greg, Kotov Roman, Klein Daniel N, Hajcak Greg
Department of Psychology, McGill University, Montréal, Quebec, Canada.
Department of Psychology, Stony Brook University, Stony Brook, New York, USA.
Psychophysiology. 2016 Mar;53(3):372-85. doi: 10.1111/psyp.12538.
The error-related negativity (ERN) currently appears as a physiological measure in relation to three Research Domain Criteria (RDoC) constructs: Cognitive Control, Sustained Threat, and Reward Learning. We propose a conceptual model in which variance in the ERN reflects individual differences in the degree to which errors are evaluated as threatening. We also discuss evidence for the placement of the ERN in the "Sustained Threat" construct, as well as evidence that the ERN may more specifically reflect sensitivity to endogenous threat. Following this, we present data from a sample of 515 adolescent females demonstrating a larger ERN in relation to self-reported checking behaviors, but only in older adolescents, suggesting that sensitivity to internal threat and the ERN-checking relationship may follow a developmental course as adolescents develop behavioral control. In contrast, depressive symptoms were linked to a smaller ERN, and this association was invariant with respect to age. Collectively, these data suggest that the magnitude of the ERN is sensitive both to specific anxiety-related processes and depression, in opposing directions that may reflect variation in internal threat sensitivity. We discuss directions for future research, as well as ways in which findings for the ERN complement and challenge aspects of the current RDoC matrix.
错误相关负波（ERN）目前作为一种生理指标，与三个研究领域标准（RDoC）结构相关：认知控制、持续威胁和奖励学习。我们提出了一个概念模型，其中ERN的差异反映了个体在将错误评估为威胁程度上的个体差异。我们还讨论了将ERN置于“持续威胁”结构中的证据，以及ERN可能更具体地反映对内源性威胁敏感性的证据。在此之后，我们展示了来自515名青春期女性样本的数据，表明与自我报告的检查行为相关的ERN更大，但仅在年龄较大的青少年中如此，这表明随着青少年发展行为控制，对内源性威胁的敏感性和ERN与检查行为的关系可能遵循一个发展过程。相比之下，抑郁症状与较小的ERN相关，并且这种关联在年龄方面是不变的。总体而言，这些数据表明ERN的大小对特定的焦虑相关过程和抑郁都敏感，且方向相反，这可能反映了内源性威胁敏感性的差异。我们讨论了未来研究的方向，以及ERN的研究结果如何补充和挑战当前RDoC矩阵的各个方面。
