Journy N, Roué T, Cardis E, Le Pointe H Ducou, Brisse H, Chateil J-F, Laurier D, Bernier M-O
Laboratory of Epidemiology, Institute for Radiological Protection and Nuclear Safety, BP 17, 92262 Fontenay-aux-Roses, France.
J Radiol Prot. 2016 Mar;36(1):N1-7. doi: 10.1088/0952-4746/36/1/N1. Epub 2016 Feb 15.
To investigate the role of cancer predisposing factors (PFs) on the associations between paediatric computed tomography (CT) scan exposures and subsequent risk of central nervous system (CNS) tumours and leukaemia. A cohort of children who underwent a CT scan in 2000-2010 in 23 French radiology departments was linked with the national childhood cancers registry and national vital status registry; information on PFs was retrieved through hospital discharge databases. In children without PF, hazard ratios of 1.07 (95% CI 0.99-1.10) for CNS tumours (15 cases) and 1.16 (95% CI 0.77-1.27) for leukaemia (12 cases) were estimated for each 10 mGy increment in CT x-rays organ doses. These estimates were similar to those obtained in the whole cohort. In children with PFs, no positive dose-risk association was observed, possibly related to earlier non-cancer mortality in this group. Our results suggest a modifying effect of PFs on CT-related cancer risks, but need to be confirmed by longer follow-up and other studies.
为研究癌症易感因素（PFs）在儿童计算机断层扫描（CT）暴露与随后中枢神经系统（CNS）肿瘤和白血病风险之间关联中的作用。对2000年至2010年期间在法国23个放射科接受CT扫描的一组儿童，将其与国家儿童癌症登记处和国家生命状况登记处进行关联；通过医院出院数据库获取PFs信息。在无PFs的儿童中，CT X线器官剂量每增加10 mGy，中枢神经系统肿瘤（15例）的风险比为1.07（95%可信区间0.99 - 1.10），白血病（12例）的风险比为1.16（95%可信区间0.77 - 1.27）。这些估计值与整个队列中获得的结果相似。在有PFs的儿童中，未观察到剂量 - 风险正相关，这可能与该组中较早的非癌症死亡率有关。我们的结果提示PFs对CT相关癌症风险有修饰作用，但需要更长时间的随访和其他研究来证实。
