[巯嘌呤的药物基因组学研究进展]
[Research advances in pharmacogenomics of mercaptopurine].
作者信息
Chen Xiao-Xiao, Shen Shu-Hong
机构信息
Department of Hematology and Oncology, Shanghai Children's Medical Center, Medical School of Shanghai Jiaotong University, Shanghai 200127, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Sep;19(9):1027-1033. doi: 10.7499/j.issn.1008-8830.2017.09.019.
Abstract
Mercaptopurine is a common chemotherapeutic drug and immunosuppressive agent and plays an important role in the treatment of acute lymphoblastic leukemia and inflammatory bowel disease. It may cause severe adverse effects such as myelosuppression, which may result in the interruption of treatment or complications including infection or even threaten patients' lives. However, the adverse effects of mercaptopurine show significant racial and individual differences, which reveal the important role of genetic diversity. Recent research advances in pharmacogenomics have gradually revealed the genetic nature of such differences. This article reviews the recent research advances in the pharmacogenomics and individualized application of mercaptopurine.
摘要
巯嘌呤是一种常用的化疗药物和免疫抑制剂，在急性淋巴细胞白血病和炎症性肠病的治疗中发挥着重要作用。它可能会引起严重的不良反应，如骨髓抑制，这可能导致治疗中断或出现包括感染在内的并发症，甚至威胁患者生命。然而，巯嘌呤的不良反应存在显著的种族和个体差异，这揭示了基因多样性的重要作用。药物基因组学的最新研究进展逐渐揭示了这些差异的遗传本质。本文综述了巯嘌呤药物基因组学及个体化应用的最新研究进展。
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本文引用的文献
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NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease.NUDT15 多态性优于巯嘌呤 S-甲基转移酶，可预测中国克罗恩病患者巯嘌呤诱导的白细胞减少症的风险。
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NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.NUDT15水解6-硫代脱氧鸟苷三磷酸以介导6-硫鸟嘌呤的抗癌疗效。
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