光学相干断层扫描血管造影评估慢性中心性浆液性脉络膜视网膜病变中不规则视网膜色素上皮脱离的血管化情况
Vascularization of Irregular Retinal Pigment Epithelial Detachments in Chronic Central Serous Chorioretinopathy Evaluated With OCT Angiography.
作者信息
de Carlo Talisa E, Rosenblatt Amir, Goldstein Michaela, Baumal Caroline R, Loewenstein Anat, Duker Jay S
出版信息
Ophthalmic Surg Lasers Imaging Retina. 2016 Feb;47(2):128-33. doi: 10.3928/23258160-20160126-05.
BACKGROUND AND OBJECTIVE
To assess eyes with flat, irregular retinal pigment epithelial detachments (RPEDs) associated with central serous chorioretinopathy (CSCR) for choroidal neovascularization (CNV) using optical coherence tomography angiography (OCTA).
MATERIALS AND METHODS
Retrospective review of OCTA images of chronic CSCR eyes with irregular RPED (group 1) and regular RPED (controls, group 2) for presence of CNV, subretinal fluid, and intraretinal fluid. Fluorescein angiography was also evaluated for CNV.
RESULTS
CNV was detected using OCTA in 13 of 31 eyes (41.9%) in group 1 and in one of 18 eyes (5.6%) in group 2 (P = .007). Irregular RPED was a risk factor for CNV (odds ratio [OR] = 12.28; 95% CI, 1.45-104.3). There was no significant difference between detection by OCTA and FA (P = 1.0). Sensitivity and specificity of detection by OCTA were 85.7% and 95.7%, respectively.
CONCLUSIONS
Irregular RPEDs in chronic CSCR eyes may harbor neovascularization more often than previously thought, which has implications on therapy.
背景与目的
使用光学相干断层扫描血管造影（OCTA）评估与中心性浆液性脉络膜视网膜病变（CSCR）相关的扁平、不规则视网膜色素上皮脱离（RPED）眼是否存在脉络膜新生血管（CNV）。
材料与方法
回顾性分析慢性CSCR伴不规则RPED眼（第1组）和规则RPED眼（对照组，第2组）的OCTA图像，观察CNV、视网膜下液和视网膜内液的情况。同时评估荧光素血管造影以检测CNV。
结果
第1组31眼中有13眼（41.9%）通过OCTA检测到CNV，第2组18眼中有1眼（5.6%）检测到CNV（P = 0.007）。不规则RPED是CNV的危险因素（比值比[OR]=12.28；95%可信区间，1.45 - 104.3）。OCTA和荧光素血管造影检测结果无显著差异（P = 1.0）。OCTA检测的敏感性和特异性分别为85.7%和95.7%。
结论
慢性CSCR眼中的不规则RPED可能比之前认为的更常伴有新生血管形成，这对治疗具有重要意义。
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