Venturina Virginia M, Alejandro Ma Antonette F, Baltazar Cyril P, Abes Nancy S, Mingala Claro N
College of Veterinary Science and Medicine, Central Luzon State University, Science City of Muñoz 3120, Nueva Ecija, Philippines.
Animal Health Unit, Philippine Carabao Center National Headquarters and Gene Pool, Science City of Muñoz 3120, Nueva Ecija, Philippines.
Ann Parasitol. 2015;61(4):283-9. doi: 10.17420/ap6104.20.
Fasciolosis caused by Fasciola spp. is considered the most important helminth infection of ruminants in tropical countries. Anthelmintic resistance has become a global concern. This study compared the efficacy of the commonly used anthelmintics, determined the toxicity level and any indication of resistance. Thirty two water buffaloes naturally-infected with Fasciola spp. were used to determine the efficacy of triclabendazole (TBZ), albendazole (ABZ), and bromofenofos (BRO) using Fecal Egg Count Reduction Test (FECRT). To test the toxicity of the drugs given, serum glutamic-pyruvic transaminase (SGPT) was evaluated before and within one week after treatment. One dose administration of ABZ registered an efficacy of 79.17%, 73.33% for TBZ and 70.83% for BRO. Efficacy in two dose- treatment group was 83.33% for both BRO and ABZ, and 90.00% for TBZ. Two dose-treatment was effective for TBZ (90%), ineffective for BRO and ABZ. SGPT levels were not significantly different between pre-treatment and post- treatment across all treatments. Giving one or two doses of anthelmintics, at one month interval, does not increase the efficacy of the three drugs tested. The study also implies that anthelmintic resistance may have developed in the animals.
由片形吸虫属引起的片形吸虫病被认为是热带国家反刍动物最重要的蠕虫感染。抗蠕虫药耐药性已成为全球关注的问题。本研究比较了常用抗蠕虫药的疗效，确定了毒性水平以及耐药性的任何迹象。使用32头自然感染片形吸虫属的水牛，通过粪便虫卵计数减少试验（FECRT）来确定三氯苯达唑（TBZ）、阿苯达唑（ABZ）和溴酚磷（BRO）的疗效。为了测试所给药物的毒性，在治疗前和治疗后一周内评估血清谷丙转氨酶（SGPT）。单剂量给药时，ABZ的疗效为79.17%，TBZ为73.33%，BRO为70.83%。两剂量治疗组中，BRO和ABZ的疗效均为83.33%，TBZ为90.00%。两剂量治疗对TBZ有效（90%），对BRO和ABZ无效。所有治疗组治疗前和治疗后的SGPT水平无显著差异。每隔一个月给予一或两剂量抗蠕虫药，并不会提高所测试的三种药物的疗效。该研究还表明动物可能已产生抗蠕虫药耐药性。
