Wang Weiwei, Dong Zhen, Zhang Jili, Zhou Xuzheng, Wei Xiaojuan, Cheng Fusheng, Li Bing, Zhang Jiyu
Key Laboratory of New Animal Drug Project of Gansu Province, Lanzhou, China.
Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou, China.
Front Vet Sci. 2019 Sep 6;6:294. doi: 10.3389/fvets.2019.00294. eCollection 2019.
Oxyclozanide is an effective anthelmintic and has shown good properties in other ways including anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity. This study aimed to investigate the acute and subacute 28-days repeated dose oral toxicity of an oxyclozanide suspension in Wistar rats. A high oral lethal dose (LD) of 3,707 mg/kg was observed in the acute toxicity test. During the 28-days time period, no obvious adverse effects or death were detected. Histopathological changes were observed in the heart, liver, and kidney of animals treated with high dose of oxyclozanide. Based on the hematological parameters, there were no statistical differences between the oxyclozanide-treated group and the control group. For biochemistry assays, ALP, AST, GLU, TBIL, GLO, TG, BUN, UA, LDH, and CK were statistically changed in the treatment groups. These data suggested that the LD of oxyclozanide was ~3,707 mg/kg body weight (BW), and the lowest observed adverse effect level (LOAEL) of oxyclozanide was at a dose of 74 mg/kg in rats.
奥昔氯生是一种有效的驱虫药，并且在其他方面也表现出良好的特性，包括抗腺病毒、抗生物膜、抗真菌和抗菌活性。本研究旨在调查奥昔氯生混悬液对Wistar大鼠的急性和亚急性28天重复剂量经口毒性。在急性毒性试验中观察到口服致死剂量（LD）高达3707 mg/kg。在28天的时间段内，未检测到明显的不良反应或死亡。在高剂量奥昔氯生治疗的动物的心脏、肝脏和肾脏中观察到组织病理学变化。基于血液学参数，奥昔氯生治疗组与对照组之间无统计学差异。对于生化检测，治疗组中的碱性磷酸酶（ALP）、天冬氨酸转氨酶（AST）、葡萄糖（GLU）、总胆红素（TBIL）、球蛋白（GLO）、甘油三酯（TG）、尿素氮（BUN）、尿酸（UA）、乳酸脱氢酶（LDH）和肌酸激酶（CK）有统计学变化。这些数据表明，奥昔氯生的LD约为3707 mg/kg体重（BW），并且奥昔氯生在大鼠中的最低观察到的有害作用水平（LOAEL）为74 mg/kg剂量。
