采用高灵敏度定量PCR方法进行嵌合体分析：嵌合体水平降至0.1以下前的中位潜伏期为6个月。 - Suppr

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超能文献

Chimerism interpretation with a highly sensitive quantitative PCR method: 6 months median latency before chimerism drop below 0.1.

作者信息

Vicente D C, Laranjeira A B A, Miranda E C M, Yunes J A, de Souza C A

机构信息

HEMOCENTRO, University of Campinas, Campinas, Brazil.

Centro Integrado de Pesquisas Oncohematológicas na Infância (CIPOI), University of Campinas, Campinas, Brazil.

出版信息

Bone Marrow Transplant. 2016 Jun;51(6):874-5. doi: 10.1038/bmt.2016.5. Epub 2016 Feb 15.

DOI:10.1038/bmt.2016.5

PMID:26878657

Abstract

摘要

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本文引用的文献

Progenitor cells trapped in marrow filters can reduce GvHD and transplant mortality.被困在骨髓滤器中的祖细胞可降低移植物抗宿主病（GVHD）和移植死亡率。

Bone Marrow Transplant. 2006 Jul;38(2):111-7. doi: 10.1038/sj.bmt.1705413. Epub 2006 Jun 5.

Reliable quantification of hematopoietic chimerism after allogeneic transplantation for acute leukemia using amplification by real-time PCR of null alleles and insertion/deletion polymorphisms.使用实时PCR扩增无效等位基因和插入/缺失多态性对急性白血病异基因移植后的造血嵌合体进行可靠定量。

Leukemia. 2005 Mar;19(3):336-43. doi: 10.1038/sj.leu.2403622.

Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: no difference in related compared with unrelated transplant in first complete remission.成年急性淋巴细胞白血病患者异基因造血干细胞移植的结果：首次完全缓解时，亲属供者移植与非亲属供者移植无差异。

J Clin Oncol. 2004 Jul 15;22(14):2816-25. doi: 10.1200/JCO.2004.07.130.

Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell transplantation: possible role for pre-emptive immunotherapy?混合嵌合体增加是急性淋巴细胞白血病儿童异基因干细胞移植后不良预后的重要预后因素：抢先免疫疗法的可能作用？

J Clin Oncol. 2004 May 1;22(9):1696-705. doi: 10.1200/JCO.2004.05.198.

Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation.预防性供体白细胞输注对接受非清髓性预处理和异基因骨髓移植治疗的晚期血液系统恶性肿瘤患者混合嵌合体、移植物抗宿主病及抗肿瘤反应的影响

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Quantification of donor and recipient hemopoietic cells by real-time PCR of single nucleotide polymorphisms.通过单核苷酸多态性的实时聚合酶链反应对供体和受体造血细胞进行定量分析。

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