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[青光眼治疗的复杂性——聚焦老年患者]

[Complexities of Medical Glaucoma Therapy--the Elderly Patient in Focus].

作者信息

Dietlein T S, Rosentreter A, Lappas A

机构信息

Augenklinik, Universitätskliniken Köln.

Augenklinik, Universität Würzburg.

出版信息

Klin Monbl Augenheilkd. 2016 Feb;233(2):138-42. doi: 10.1055/s-0041-110447. Epub 2016 Feb 15.

Abstract

In order to treat glaucoma with medication successfully, the patient needs to participate actively in the process. "Adherence", formerly "compliance", describes the willingness and capacity to follow the prescribed regimen every day. It is not trivial to measure adherence and persistence, as this quite often relies on self reports by the patient or speculations by the physician. Hence, the overall reported adherence may vary from 5 to 95 %. In general, the following categories have been defined for reduced adherence: medication-related factors, patient-related factors, environmental factors and social factors. Age has been found to intensify or modify many of these factors. Older adults often face various challenges, due to motor disabilities, reduced visual acuity or impaired cognitive capabilities. In patients with movement disorders or tactile limitations, the target area can be reached more successfully with standard eye drop bottles than with single-use dose units. This should be considered if antiglaucoma eye drops are prescribed in the elderly. Frequency of application is a main factor influencing adherence. Monotherapy--as provided with prostaglandins--or drops with a fixed combination have proven to support adherence significantly. A significant boost for self-monitoring activities is initiated by the growing market of electronic devices, like smartphones. For instance, they can provide acoustic alarms as reminders to apply the eye drops. It is evident that any external support or disease-related information by family members, the medical practitioners, support groups or even electronic devices may improve adherence and persistence, even in patients with severe impairments.

摘要

为了成功地使用药物治疗青光眼,患者需要积极参与这一过程。“依从性”,以前称为“顺应性”,描述的是每天遵循规定治疗方案的意愿和能力。测量依从性和持续性并非易事,因为这通常依赖于患者的自我报告或医生的推测。因此,总体报告的依从性可能在5%至95%之间。一般来说,依从性降低可分为以下几类:药物相关因素、患者相关因素、环境因素和社会因素。研究发现年龄会强化或改变其中许多因素。老年人由于运动障碍、视力下降或认知能力受损,往往面临各种挑战。对于患有运动障碍或触觉受限的患者,使用标准眼药水滴管比使用一次性剂量单位能更成功地到达目标区域。如果为老年人开抗青光眼眼药水,应考虑这一点。用药频率是影响依从性的一个主要因素。前列腺素类单药治疗或固定复方滴眼液已被证明能显著提高依从性。电子设备(如智能手机)市场的不断增长,为自我监测活动带来了显著推动。例如,它们可以提供声音警报作为滴眼药水的提醒。很明显,家庭成员、医生、支持小组甚至电子设备提供的任何外部支持或疾病相关信息,都可能提高依从性和持续性,即使是对严重受损的患者也是如此。

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