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在“Chiniy-trèf”中检测马兜铃酸I和II,“Chiniy-trèf”是法属西印度群岛马提尼克岛一种传统药物制剂,其中含有以马兜铃属植物马兜铃为食的毛虫。

Detection of aristolochic acids I and II in "Chiniy-trèf", a traditional medicinal preparation containing caterpillars feeding on Aristolochia trilobata L. in Martinique, French West Indies.

作者信息

Cachet Xavier, Langrand Jerome, Bottai Cecile, Dufat Hanh, Locatelli-Jouans Corinne, Nossin Emmanuel, Boucaud-Maitre Denis

机构信息

Laboratoire de Pharmacognosie, UMR 8638 COMETE CNRS, Faculté de Pharmacie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Centre Antipoison de Paris, AP-HP Hôpital Lariboisière, Paris, France.

出版信息

Toxicon. 2016 May;114:28-30. doi: 10.1016/j.toxicon.2016.02.013. Epub 2016 Feb 12.

DOI:10.1016/j.toxicon.2016.02.013
PMID:26879332
Abstract

"Chiniy-trèf" is a traditional medicinal preparation used in Martinique, French West Indies, for the prevention of all kinds of attempted poisoning and hex. It is produced by the maceration in alcohol (mostly rum) of larvae (caterpillars) of the butterfly Battus polydamas ssp. cebriones, feeding on the leaves of Aristolochia trilobata. Aristolochic acids I and II that are well-known nephrotoxic and carcinogenic substances were identified on two samples of "chiniy-trèfl" by chromatographic methods.

摘要

“Chiniy-trèf”是法属西印度群岛马提尼克岛用于预防各类中毒企图和诅咒的一种传统药物制剂。它由以三叶马兜铃叶为食的多音凤蝶(Battus polydamas ssp. cebriones)幼虫(毛虫)在酒精(主要是朗姆酒)中浸渍制成。通过色谱法在两份“chiniy-trèfl”样品中鉴定出了已知具有肾毒性和致癌性的马兜铃酸I和II。

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Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms.
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