硫酸吲哚酚对慢性肾脏病新生血管形成的有害作用。

The harmful effect of indoxyl sulfate on neovascularization in chronic kidney disease.

机构信息

Aix Marseille Université, Inserm, Vascular Research Center of Marseille UMR_S 1076, Marseille, France.

Aix Marseille Université, Inserm, Vascular Research Center of Marseille UMR_S 1076, Marseille, France; Assistance Publique-Hôpitaux de Marseille, CHU Conception, Centre de Néphrologie Dialyse Transplantation Rénale, Marseille, France.

出版信息

Kidney Int. 2016 Mar;89(3):532-4. doi: 10.1016/j.kint.2015.12.030.

DOI:10.1016/j.kint.2015.12.030

PMID:26880447

Abstract

Patients with chronic kidney disease display an impairment of neovascularization in ischemic tissues. Studies have suggested the involvement of the uremic toxin indoxyl sulfate by demonstrating that indoxyl sulfate affects endothelial progenitor cells. However, few data are available on the effects of indoxyl sulfate on neovascularization and on the mechanisms involved. The article by Hung et al. shows that indoxyl sulfate suppresses neovascularization in uremic mice by impairing endothelial progenitor cell function via the inhibition of hypoxia-induced hypoxia-inducible factor/interleukin-10/vascular endothelial growth factor signaling.

摘要

患有慢性肾病的患者在缺血组织中的新生血管形成能力受损。有研究表明，尿毒症毒素吲哚硫酸酯通过影响内皮祖细胞而参与其中。然而，关于吲哚硫酸酯对新生血管形成的影响及其相关机制的资料还很有限。Hung 等人的文章表明，吲哚硫酸酯通过抑制缺氧诱导的低氧诱导因子/白细胞介素-10/血管内皮生长因子信号通路来损害内皮祖细胞的功能，从而抑制尿毒症小鼠的新生血管形成。