Hu Shanshan, Shan Ge
School of Life Sciences and CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei, Anhui 230027, China.
Stem Cells Int. 2016;2016:2681925. doi: 10.1155/2016/2681925. Epub 2016 Jan 6.
Noncoding RNAs are critical regulatory factors in essentially all forms of life. Stem cells occupy a special position in cell biology and Biomedicine, and emerging results show that multiple ncRNAs play essential roles in stem cells. We discuss some of the known ncRNAs in stem cells such as embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, adult stem cells, and cancer stem cells with a focus on long ncRNAs. Roles and functional mechanisms of these lncRNAs are summarized, and insights into current and future studies are presented.
非编码RNA在几乎所有生命形式中都是关键的调控因子。干细胞在细胞生物学和生物医学中占据特殊地位，并且新出现的结果表明多种非编码RNA在干细胞中发挥着重要作用。我们讨论了干细胞（如胚胎干细胞、诱导多能干细胞、间充质干细胞、成体干细胞和癌症干细胞）中一些已知的非编码RNA，重点是长链非编码RNA。总结了这些长链非编码RNA的作用和功能机制，并对当前和未来的研究提出了见解。
