Bashandy Samir A E, El Awdan Sally A, Ebaid Hossam, Alhazza Ibrahim M
Pharmacology Department, National Research Center, El Buhouth Street, Dokki, Giza 12311, Egypt.
Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Zoology Department, College of Science, Minia University, Minia 11432, Egypt.
Oxid Med Cell Longev. 2016;2016:7174351. doi: 10.1155/2016/7174351. Epub 2016 Jan 13.
The present study aimed to examine the protective role of Spirulina platensis (S. platensis) against arsenic-induced testicular oxidative damage in rats. Arsenic (in the form of NaAsO2 at a dose of 6.3 mg/kg body weight for 8 weeks) caused a significant accumulation of arsenic in testicular tissues as well as a decrease in the levels of testicular superoxide dismutase (SOD), catalase (CAT), reduced glutathione, and zinc. Moreover, it significantly decreased plasma testosterone, luteinizing hormone (LH), triiodothyronine (T3), and thyroxine (T4) levels and reduced sperm motility and sperm count. Arsenic (AS) led to a significant increase in testicular malondialdehyde (MDA), tumour necrosis factor alpha (TNF-α), nitric oxide (NO), and sperm abnormalities. S. platensis at a dose of 300 mg/kg was found to attenuate As-induced oxidative stress, testicular damage, and sperm abnormalities by its potent antioxidant activity. S. platensis may represent a potential therapeutic option to protect the testicular tissue from arsenic intoxication.
本研究旨在探讨钝顶螺旋藻对砷诱导的大鼠睾丸氧化损伤的保护作用。砷（以亚砷酸钠形式，剂量为6.3毫克/千克体重，持续8周）导致睾丸组织中砷显著蓄积，同时睾丸超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、还原型谷胱甘肽和锌水平降低。此外，它还显著降低血浆睾酮、黄体生成素（LH）、三碘甲状腺原氨酸（T3）和甲状腺素（T4）水平，并降低精子活力和精子数量。砷导致睾丸丙二醛（MDA）、肿瘤坏死因子α（TNF-α）、一氧化氮（NO）显著增加以及精子异常。发现剂量为300毫克/千克的钝顶螺旋藻通过其强大的抗氧化活性减轻砷诱导的氧化应激、睾丸损伤和精子异常。钝顶螺旋藻可能是保护睾丸组织免受砷中毒的一种潜在治疗选择。
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