Cai Xue, McGinnis James F
Department of Ophthalmology, Dean McGee Eye Institute, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.
Department of Ophthalmology, Dean McGee Eye Institute, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Cell Biology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA; Oklahoma Center for Neuroscience, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.
J Diabetes Res. 2016;2016:3789217. doi: 10.1155/2016/3789217. Epub 2016 Jan 6.
Diabetic retinopathy (DR) is one of the major complications of diabetes. Although great efforts have been made to uncover the mechanisms underlying the pathology of DR, the exact causes of DR remain largely unknown. Because of multifactor involvement in DR etiology, currently no effective therapeutic treatments for DR are available. In this paper, we review the pathology of DR, commonly used animal models, and novel therapeutic approaches. Perspectives and future directions for DR treatment are discussed.
糖尿病视网膜病变(DR)是糖尿病的主要并发症之一。尽管人们为揭示DR病理机制付出了巨大努力,但DR的确切病因仍 largely unknown。由于DR病因涉及多因素,目前尚无有效的DR治疗方法。本文综述了DR的病理、常用动物模型及新型治疗方法。并讨论了DR治疗的前景和未来方向。 (注:“largely unknown”直译为“很大程度上未知”,这里意译为“仍不清楚”更通顺)