Molomo Edward M, Bouckaert Michael, Khammissa Razia A G, Motswaledi Hendrick M, Lemmer Johan, Feller Liviu
Department of Periodontology and Oral Medicine, Faculty of Health Sciences, University of Limpopo, Medunsa Campus, South Africa.
J Cancer Res Ther. 2015 Oct-Dec;11(4):1036. doi: 10.4103/0973-1482.146107.
Discoid lupus erythematosus (DLE) is an autoimmune disease commonly affecting sun-exposed areas of the skin. Subjects with DLE have high-levels of plasmacytoid dendritic cells -derived interferon-α, which mediates both loss of immune tolerance to self-antigens and exaggerated inflammatory state, and supports proliferation and differentiation of hyperactive B-cells. In a few cases, DLE of the lips, scalp, ears or nose may eventually progress to squamous cell carcinoma (SCC). Photosensitivity and the long-standing immune-mediated chronic inflammation and dysregulated healing characterized by atrophy, hypopigmentation or scarring inherent to DLE are risk factors for progression to SCC. We review some aspects of the pathogenesis of DLE and the possible roles of inflammation and photosensitivity in the carcinomatous transformation of DLE keratinocytes, and present an illustrative case of DLE of the lower lip in an HIV-tuberculosis co-infected black person, that progressed to SCC.
盘状红斑狼疮（DLE）是一种自身免疫性疾病，通常影响皮肤的暴露于阳光下的区域。患有DLE的受试者具有高水平的浆细胞样树突状细胞衍生的干扰素-α，其介导对自身抗原的免疫耐受性丧失和过度炎症状态，并支持活跃的B细胞的增殖和分化。在少数情况下，嘴唇、头皮、耳朵或鼻子的DLE最终可能进展为鳞状细胞癌（SCC）。光敏性以及以DLE固有的萎缩、色素减退或瘢痕形成特征的长期免疫介导的慢性炎症和愈合失调是进展为SCC的危险因素。我们回顾了DLE发病机制的一些方面以及炎症和光敏性在DLE角质形成细胞癌变转化中的可能作用，并展示了一例HIV-结核合并感染的黑人下唇DLE进展为SCC的病例。
Zotero 插件