四溴化碳介导的氧化C-N键形成：应用于咪唑并[1,2-α]吡啶和咪唑并[1,2-α]嘧啶的合成。
CBr4 Mediated Oxidative C-N Bond Formation: Applied in the Synthesis of Imidazo[1,2-α]pyridines and Imidazo[1,2-α]pyrimidines.
作者信息
Huo Congde, Tang Jing, Xie Haisheng, Wang Yajun, Dong Jie
机构信息
Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University , Lanzhou, Gansu 730070, China.
出版信息
Org Lett. 2016 Mar 4;18(5):1016-9. doi: 10.1021/acs.orglett.6b00137. Epub 2016 Feb 16.
PMID:26882001
Abstract
The carbon tetrabromide mediated oxidative carbon-nitrogen bond formation of 2-aminopyridines or 2-aminopyrimidines with β-keto esters or 1,3-diones, leading to a variety of complex imidazo[1,2-α]pyridines or imidazo[1,2-α]pyrimidines, is reported. The reactions were realized under mild and metal-free conditions.
摘要
据报道，四溴化碳介导2-氨基吡啶或2-氨基嘧啶与β-酮酯或1,3-二酮形成碳-氮键，从而生成多种复杂的咪唑并[1,2-α]吡啶或咪唑并[1,2-α]嘧啶。这些反应是在温和且无金属的条件下实现的。
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