Fang Yiwen, Fullwood Melissa J
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore; Yale-NUS Liberal Arts College, Singapore 138527, Singapore.
Genomics Proteomics Bioinformatics. 2016 Feb;14(1):42-54. doi: 10.1016/j.gpb.2015.09.006. Epub 2016 Feb 12.
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.
长链非编码RNA（lncRNAs）在癌症中发挥着重要作用。它们通过多种基于染色质的机制以及与其他RNA种类的相互作用，参与染色质重塑以及转录和转录后调控。lncRNAs可以充当诱饵、支架和增强子RNA。本综述总结了lncRNAs的特征，包括它们的作用、功能和作用机制，描述了鉴定和注释lncRNAs的方法，并讨论了使用反义寡核苷酸进行基于lncRNA的治疗的未来机遇。
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