在植入前基因诊断/植入前基因筛查周期中进行玻璃化/复温单囊胚移植
Vitrified/warmed single blastocyst transfer in preimplantation genetic diagnosis/preimplantation genetic screening cycles.
作者信息
Huang Jin, Li Rong, Lian Ying, Chen Lixue, Shi Xiaodan, Qiao Jie, Liu Ping
机构信息
Department of Obstetrics and Gynecology, Reproductive Medical Centre, Peking University Third HospitalBeijing 100191, China; Key Laboratory of Assisted Reproduction, Ministry of Education and Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive TechnologyBeijing 100191, China.
Department of Obstetrics and Gynecology, Reproductive Medical Centre, Peking University Third Hospital Beijing 100191, China.
出版信息
Int J Clin Exp Med. 2015 Nov 15;8(11):21605-10. eCollection 2015.
OBJECTIVE
To investigate the single blastocyst transfer in preimplantation genetic diagnosis (PGD)/preimplantation genetic screening (PGS) cycles.
METHODS
80 PGD/PGS cycles undergoing blastocyst biopsy were studied. There were 88 warming cycles during the study period. Only one warmed blastocyst was transferred per cycle. The outcomes were followed up to the infants were born.
RESULTS
The embryo implantation rate was 54.55% (48/88). The clinical pregnancy rate was 54.55% (48/88) per transfer cycle and 60% (48/80) per initial PGD/PGS cycle. There was no multi-pregnant in this study. The live birth rate was 42.05% (37/88) per transfer cycle and 46.25% (37/80) per initial PGD/PGS cycle.
CONCLUSION
In PGD/PGS cycles, single blastocyst transfer reduces the multiple pregnancy rate without affecting the clinical outcomes.
目的
探讨胚胎植入前遗传学诊断（PGD）/胚胎植入前遗传学筛查（PGS）周期中的单囊胚移植情况。
方法
对80个接受囊胚活检的PGD/PGS周期进行研究。研究期间有88个复苏周期。每个周期仅移植1个复苏后的囊胚。对结果进行随访直至婴儿出生。
结果
胚胎着床率为54.55%（48/88）。每个移植周期的临床妊娠率为54.55%（48/88），每个初始PGD/PGS周期的临床妊娠率为60%（48/80）。本研究中无多胎妊娠情况。每个移植周期的活产率为42.05%（37/88），每个初始PGD/PGS周期的活产率为46.25%（37/80）。
结论
在PGD/PGS周期中，单囊胚移植可降低多胎妊娠率，且不影响临床结局。
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