Roquefeuil B, Baldy-Moulinier M, Frerebeau P, Viguie E, Escuret E
Neurochirurgie. 1977;23(5):401-12.
In 34 comatose patients in the acute phase, the mean hemispheric CBF is lowered as well as the CMRO2, with a quite good relation between these values and the coma level and prognostic so. The cerebral response to a PaCO2 range indicates a quite good relation with the coma level (the lowest value in the most severe comas). The cerebral autoregulation study, using Aramine induced hypertension, can separate the cases with a present autoregulation and the cases with a loss of autoregulation (the most severe and the poorest prognosis). In dynamic conditions (variation of the PaCO2 or Aramine induced hypertension), the change in CMRO2 is interesting : rather good prognosis among the patients with a normal metabolic autoregulation - poor prognosis among those whose metabolic autoregulation is lost.
在34例处于急性期的昏迷患者中,半球平均脑血流量(CBF)以及脑氧代谢率(CMRO2)均降低,这些值与昏迷程度及预后之间存在相当良好的关系。大脑对一定范围的动脉血二氧化碳分压(PaCO2)的反应表明其与昏迷程度有相当良好的关系(在最严重的昏迷中该值最低)。使用阿拉明诱导高血压进行的脑自动调节研究,可以区分存在自动调节的病例和自动调节丧失的病例(最严重且预后最差)。在动态条件下(PaCO2变化或阿拉明诱导高血压),CMRO2的变化很有意思:代谢自动调节正常的患者预后较好,而代谢自动调节丧失的患者预后较差。