Yi Sang-Wook, Jung Myoungjee, Kimm Heejin, Sull Jae-Woong, Lee Eunsook, Lee Kwang Ok, Ohrr Heechoul
Department of Preventive Medicine and Public Health, Catholic Kwandong University College of Medicine, Gangneung, Republic of Korea Institute for Clinical and Translational Research, Catholic Kwandong University College of Medicine, Gangneung, Republic of Korea.
Department of Public Health, Yonsei University Graduate School, Seoul, Republic of Korea.
J Epidemiol Community Health. 2016 Aug;70(8):778-83. doi: 10.1136/jech-2015-206849. Epub 2016 Feb 17.
The evidence from prospective studies on whether greater usual alcohol consumption is associated with a higher risk of death by suicide in the general population is inconclusive.
6163 participants (2635 men; 3528 women) in a 1985 survey among rural residents in Korea aged 55 years and above were followed until 2008. A Cox model was used to calculate HRs of suicide death after adjustment for demographic, socioeconomic and health-related confounders.
37 men and 24 women died by suicide. Elderly persons who consumed alcohol daily, 70 g alcohol (5 drinks) or more per drinking day, or 210 g alcohol (15 drinks) or more per week had higher suicide mortality (p<0.05), compared with non-drinkers. An increase of one drinking day per week (HR=1.17, 95% CI 1.05 to 1.31), 70 g (5 drinks) additional alcohol intake per drinking day (HR=1.38, 95% CI 1.13 to 1.70), and 140 g (10 drinks) additional alcohol intake per week was associated with a 17%, 38% and 12% higher risk of suicide death, respectively. Women had a higher relative risk of suicide death associated with alcohol consumption, compared with men.
A greater frequency and amount of usual alcohol consumption was linearly associated with higher suicide death. Given the same amount of alcohol consumption, women might have a higher relative risk of suicide than men. Our findings support 'the lower the better' for alcohol intake, no protective effect of moderate alcohol consumption, and a sex-specific guideline (lower alcohol threshold for women) as actions to prevent suicide death.
关于在一般人群中,通常饮酒量增加是否与自杀死亡风险升高相关的前瞻性研究证据尚无定论。
对1985年韩国55岁及以上农村居民调查中的6163名参与者(2635名男性;3528名女性)进行随访至2008年。采用Cox模型在对人口统计学、社会经济和健康相关混杂因素进行调整后计算自杀死亡的风险比(HR)。
37名男性和24名女性自杀死亡。与不饮酒者相比,每日饮酒、每日饮酒量70克酒精(5杯)或更多、或每周饮酒量210克酒精(15杯)或更多的老年人自杀死亡率更高(p<0.05)。每周饮酒天数增加一天(HR=1.17,95%可信区间1.05至1.31)、每日额外饮酒量70克(5杯)酒精(HR=1.38,95%可信区间1.13至1.70)以及每周额外饮酒量140克(10杯)分别与自杀死亡风险升高17%、38%和12%相关。与男性相比,女性因饮酒导致自杀死亡的相对风险更高。
通常饮酒的频率和量增加与更高的自杀死亡呈线性相关。在饮酒量相同的情况下,女性自杀的相对风险可能高于男性。我们的研究结果支持饮酒量“越低越好”,适度饮酒无保护作用,以及制定针对性别的指导方针(女性饮酒阈值更低)作为预防自杀死亡的措施。