Ellimoottil Chandy, Roghmann Florian, Blackwell Robert, Kadlec Adam, Greco Kristin, Quek Marcus L, Sun Maxine, Trinh Quoc-Dien, Gupta Gopal
Loyola University Medical Center, Maywood, IL., USA.
Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada; Department of Urology, Ruhr University Bochum, Marienhospital, Herne, Germany.
Curr Urol. 2015 Sep;8(3):156-61. doi: 10.1159/000365708. Epub 2015 Sep 4.
Robotic-assisted radical prostatectomy (RARP) has been shown to reduce blood loss, peri-operative complications and length of stay when compared to open radical prostatectomy (ORP). We sought to determine whether the reported benefits of RARP over ORP translate to obese patients.
We utilized the 2009-2010 Nationwide Inpatient Sample to identify all obese men with prostate cancer who underwent ORP and RARP. Our primary outcome was the presence of a peri-operative adverse event (i.e. blood transfusion, complication, prolonged length of stay). We fit multivariable logistic regression models to examine whether RARP in obese patients was independently associated with decreased odds of all three outcomes.
We identified 9,108 obese patients who underwent radical prostatectomy. On multivariable analysis, the use of RARP in the obese population was not independently associated with decreased odds of developing a peri-operative complication (OR = 0.81, CI: 0.58-1.13, p = 0.209). RARP was, however, associated with decreased odds of blood transfusion (OR = 0.17, CI: 0.10-0.30, p < 0.001) and prolonged length of stay (OR = 0.28, CI: 0.20-0.40, p < 0.001).
Our findings suggest that in obese patients, the use of RARP may reduce length of stay and blood transfusions compared to ORP. Both approaches, however, are associated with similar odds of developing a complication.
与开放性根治性前列腺切除术(ORP)相比,机器人辅助根治性前列腺切除术(RARP)已被证明可减少失血、围手术期并发症及住院时间。我们试图确定RARP相对于ORP所报告的益处是否适用于肥胖患者。
我们利用2009 - 2010年全国住院患者样本,识别所有接受ORP和RARP的肥胖前列腺癌男性患者。我们的主要结局是围手术期不良事件的发生情况(即输血、并发症、住院时间延长)。我们拟合多变量逻辑回归模型,以检验肥胖患者接受RARP是否与这三种结局发生几率降低独立相关。
我们识别出9108例接受根治性前列腺切除术的肥胖患者。多变量分析显示,肥胖人群中使用RARP与围手术期并发症发生几率降低无独立相关性(OR = 0.81,CI:0.58 - 1.13,p = 0.209)。然而,RARP与输血几率降低(OR = 0.17,CI:0.10 - 0.30,p < 0.001)及住院时间延长几率降低(OR = 0.28,CI:0.20 - 0.40,p < 0.001)相关。
我们的研究结果表明,在肥胖患者中,与ORP相比,使用RARP可能会减少住院时间和输血情况。然而,两种手术方式发生并发症的几率相似。