慢性肛周克罗恩病引发的腺癌：一例报告

Adenocarcinoma arising from chronic perianal crohn's disease: a case report.

作者信息

Massit Hanane, Edderai Meryem, Saouab Rachida, Seddik Hassan, El Fenni Jamal, Benkirane Ahmed

机构信息

Department of Gastroenterology II, Mohamed V Teaching Military Hospital, Mohamed V-Souissi University, Rabat, Morocco.

Department of Radiology, Mohamed V Teaching Military Hospital, Mohamed V-Souissi University, Rabat, Morocco.

出版信息

Pan Afr Med J. 2015 Oct 14;22:140. doi: 10.11604/pamj.2015.22.140.7875. eCollection 2015.

DOI:10.11604/pamj.2015.22.140.7875

PMID:26889321

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4742036/

Abstract

Malignant transformation of perineal fistula in Crohn's disease has rarely been reported. We report a case of Crohn's disease with recurrent perineal fistulas. A 36-year-old male, diagnosed with Crohn's disease at the age of 24, developed adenocarcinoma in an anorectal fistula that had existed for years. He was treated with adjuvant chemoradiotherapy but died. A high index of suspicion and regular surveillance is recommended in chronic anorectal fistulas in Crohn's disease. The shorter duration of Crohn's fistulas prior to malignant degeneration necessitates an aggressive approach to rule out cancer.

摘要

克罗恩病会阴瘘的恶性转化鲜有报道。我们报告一例复发性会阴瘘的克罗恩病病例。一名36岁男性，24岁时被诊断为克罗恩病，在一个已存在数年的肛肠瘘中发生了腺癌。他接受了辅助放化疗，但最终死亡。对于克罗恩病的慢性肛肠瘘，建议保持高度怀疑并进行定期监测。克罗恩病瘘在发生恶性退变之前的病程较短，因此需要采取积极的方法来排除癌症。