Consorti F, Lorenzotti A, Midiri G, Di Paola M
Dipartimento Scienze Chirurgiche e Tecnologie Mediche Applicate, Università 'La Sapienza' di Roma, Roma, Italy.
J Surg Oncol. 2000 Feb;73(2):70-4. doi: 10.1002/(sici)1096-9098(200002)73:2<70::aid-jso3>3.0.co;2-j.
The clinical meaning of mucinous type of colonic and rectal carcinoma is still controversial. We used clinicopathological and follow-up data prospectively recorded for our series of colon and rectum cancer to compare 2 matched groups of mucinous and nonmucinous cancer patients.
Two-hundred-forty-eight patients operated for colon and rectum cancer between January 1986 and January 1997 were considered. Thirty-six patients showed mucinous pattern on histologic examination but only 29 (11.7%) had more than 50% of mucin-secreting acini and could be classified as mucinous type. The 29 mucinous cancer patients were compared with 212 nonmucinous cancer patients to evaluate differences in epidemiological and clinical features. A control group from the nonmucinous patients was sorted by matching for age, sex, location, and Dukes stage.
In the case-control groups, survival was better for nonmucinous than for mucinous tumours. Many of the epidemiological findings already observed for mucinous carcinoma were also confirmed.
The existence of prognostic, clinical, and epidemiological differences between mucinous and nonmucinous colorectal carcinoma, together with the preliminary reports about their difference as to genetic features, could support the hypothesis that mucinous type is a distinct biological entity.
结直肠癌黏液型的临床意义仍存在争议。我们利用对一系列结肠癌和直肠癌患者前瞻性记录的临床病理及随访数据，比较两组匹配的黏液性和非黏液性癌症患者。
纳入1986年1月至1997年1月间接受结肠癌和直肠癌手术的248例患者。36例患者在组织学检查中显示黏液样模式，但只有29例（11.7%）的黏蛋白分泌腺泡超过50%，可归类为黏液型。将29例黏液性癌患者与212例非黏液性癌患者进行比较，以评估流行病学和临床特征的差异。从非黏液性患者中选取一个对照组，按照年龄、性别、肿瘤位置和杜克分期进行匹配。
在病例对照研究组中，非黏液性肿瘤患者的生存率高于黏液性肿瘤患者。许多已观察到的黏液性癌的流行病学发现也得到了证实。
黏液性和非黏液性结直肠癌在预后、临床和流行病学方面存在差异，以及关于它们在基因特征方面差异的初步报告，可能支持黏液型是一种独特生物学实体的假说。
