Tai Xiaochen, Chen Yue
School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Environ Res. 2016 May;147:172-8. doi: 10.1016/j.envres.2016.02.006. Epub 2016 Feb 15.
Bisphenol A (BPA), an endocrine disrupting chemical (EDC), may pose a risk to human health, including diabetes. However, epidemiological studies from the U.S., China and South Korea showed inconsistent results.
To examine the associations between BPA and indicators of diabetes in the general Canadian population.
The analysis was based on cross-sectional data from the Canadian Health Measures Survey (CHMS) Cycle 2 (2009-2011). We included 1915 participants with glycated hemoglobin (HbA1c) measurement and 2405 participants with serum glucose (SG) measurement aged 3-79 years, respectively. Multiple linear regression analyses were performed to model HbA1c and log-transformed SG levels associated with quartiles of urinary BPA concentrations controlling for potential confounders. Further, in adults (age≥18 years), logistic regression analysis was conducted to evaluate the association between BPA and physician-diagnosed diabetes mellitus (DM). Bootstrap weights were applied to all the analyses to account for the complex survey design.
The geometric mean of urinary BPA was 1.21 (±0.05)µg/L. Overall, a positive association was observed between urinary BPA quartiles and HbA1c levels in men after controlling for potential confounders (P<0.05), but not in women and children. Similar patterns were found for the associations of BPA with log-transformed SG levels and doctor-diagnosed DM.
Higher urinary BPA levels were associated with adverse glucose homeostasis in Canadian men, independent of major covariates. Prospective studies with longitudinal design are needed to further investigate the causality.
双酚A（BPA）是一种内分泌干扰化学物质（EDC），可能对人类健康构成风险，包括糖尿病。然而，来自美国、中国和韩国的流行病学研究结果并不一致。
研究加拿大普通人群中双酚A与糖尿病指标之间的关联。
分析基于加拿大健康措施调查（CHMS）第2周期（2009 - 2011年）的横断面数据。我们分别纳入了1915名进行糖化血红蛋白（HbA1c）测量的参与者和2405名进行血清葡萄糖（SG）测量的3至79岁参与者。进行多元线性回归分析，以模拟糖化血红蛋白和对数转换后的血清葡萄糖水平与尿双酚A浓度四分位数之间的关联，并控制潜在的混杂因素。此外，在成年人（年龄≥18岁）中，进行逻辑回归分析以评估双酚A与医生诊断的糖尿病（DM）之间的关联。对所有分析应用自助权重以考虑复杂的调查设计。
尿双酚A的几何平均值为1.21（±0.05）μg/L。总体而言，在控制潜在混杂因素后，男性尿双酚A四分位数与糖化血红蛋白水平之间存在正相关（P<0.05），但在女性和儿童中未观察到这种相关性。双酚A与对数转换后的血清葡萄糖水平和医生诊断的糖尿病之间的关联也呈现类似模式。
在加拿大男性中尿液双酚A水平较高与不良的葡萄糖稳态相关，且独立于主要协变量。需要进行纵向设计的前瞻性研究以进一步探究因果关系。
