Department of Pharmacy, Keimyung University, Daegu, Republic of Korea.
Int J Hyg Environ Health. 2013 Jul;216(4):467-71. doi: 10.1016/j.ijheh.2012.07.007. Epub 2012 Aug 24.
Bisphenol A (BPA) is a synthetic phenolic compound to which the general public may be exposed via consumer products and environmental contamination. We assessed the association between urinary BPA concentration and the prevalence of type 2 diabetes. This cross-sectional study included Korean adult participants (n=1210) aged 40-69 years and was based on the 2009 Korean National Human Biomonitoring Survey. Demographic characteristics and medical history of type 2 diabetes were collected from the participants by questionnaire, and BPA levels were determined by analysis of urine samples. The mean age of the participants was 53.4 years and 41.6% were men; the prevalence of type 2 diabetes differed according to demographic characteristics. The geometric mean urinary BPA levels of participants with and without type 2 diabetes were 2.03 and 2.40ng/mL, respectively. Among BPA quartiles, no clear association was found between BPA levels and type 2 diabetes. Although the adjusted odds ratio of type 2 diabetes was slightly increased for participants in the upper BPA quartile, the association was not statistically significant. These findings suggest that a high body BPA burden may not be associated with an increased prevalence of type 2 diabetes in Korean adults.
双酚 A（BPA）是一种合成酚类化合物，公众可能会通过消费产品和环境污染接触到它。我们评估了尿中 BPA 浓度与 2 型糖尿病患病率之间的关系。这项横断面研究包括年龄在 40-69 岁的韩国成年参与者（n=1210），并基于 2009 年韩国国家人体生物监测调查。通过问卷收集参与者的人口统计学特征和 2 型糖尿病病史，通过尿液样本分析确定 BPA 水平。参与者的平均年龄为 53.4 岁，其中 41.6%为男性；2 型糖尿病的患病率根据人口统计学特征而有所不同。患有和不患有 2 型糖尿病的参与者的尿中 BPA 几何平均值分别为 2.03 和 2.40ng/mL。在 BPA 四分位数中，BPA 水平与 2 型糖尿病之间没有明显的关联。尽管上四分位数 BPA 水平的参与者发生 2 型糖尿病的调整比值比略有增加，但关联没有统计学意义。这些发现表明，韩国成年人高身体 BPA 负担可能与 2 型糖尿病患病率的增加无关。
