Madore Matthew P, Sakaki Junichi R, Chun Ock K
Department of Nutritional Science, University of Connecticut, 27 Manter Road, Unit 4017, Storrs, CT 06269-4017 USA.
Food Sci Biotechnol. 2022 Jul 12;31(8):905-934. doi: 10.1007/s10068-022-01105-z. eCollection 2022 Jul.
Endocrine disrupting chemicals (EDCs) are a heterogenous group of compounds dispersed throughout the environment that possess the ability to alter endocrine system function. While there are numerous routes of exposure to EDCs, the predominant source of many of these compounds is diet, largely due to their widespread use in food contact materials. In recent years, there has been a surge of research aimed at assessing exposure to EDCs, identifying their health implications, and developing approaches to minimize the risks they may entail. Due to their antioxidant and anti-inflammatory potential, polyphenols have been purported to confer protection against EDC-induced health detriments. This review discusses the evidence pertaining to dietary exposure to the two predominant EDCs, bisphenol A and phthalates, in the United States, their associations with diabetes, cancer, and cardiovascular disease outcomes, the potential for polyphenols to mitigate their disease-promoting effects, gaps in knowledge, and recommendations for future research.
内分泌干扰化学物质（EDCs）是一类分布于环境中的异质化合物，具有改变内分泌系统功能的能力。虽然接触EDCs的途径众多，但这些化合物的许多主要来源是饮食，这主要是因为它们在食品接触材料中广泛使用。近年来，旨在评估EDCs暴露情况、确定其对健康的影响以及开发降低其可能带来风险的方法的研究激增。由于多酚具有抗氧化和抗炎潜力，有人认为多酚可预防EDCs对健康造成的损害。本综述讨论了与美国饮食中两种主要EDCs（双酚A和邻苯二甲酸盐）暴露相关的证据、它们与糖尿病、癌症和心血管疾病结局的关联、多酚减轻其促疾病作用的潜力、知识空白以及对未来研究的建议。
