Department of Oral Microbiology and Immunology, School of Dentistry, Kyungpook National University, Daegu, 700-412, Korea.
Laboratory of Molecular Cell Biology, Department of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt.
Phytother Res. 2016 May;30(5):754-67. doi: 10.1002/ptr.5592. Epub 2016 Feb 18.
Cinnamaldehyde and cinnamaldehyde-derived compounds are candidates for the development of anticancer drugs that have received extensive research attention. In this review, we summarize recent findings detailing the positive and negative aspects of cinnamaldehyde and its derivatives as potential anticancer drug candidates. Furthermore, we describe the in vivo pharmacokinetics and metabolism of cinnamaldehydes. The oxidative and antioxidative properties of cinnamaldehydes, which contribute to their potential in chemotherapy, have also been discussed. Moreover, the mechanism(s) by which cinnamaldehydes induce apoptosis in cancer cells have been explored. In addition, evidence of the regulatory effects of cinnamaldehydes on cancer cell invasion and metastasis has been described. Finally, the application of cinnamaldehydes in treating various types of cancer, including breast, prostate, and colon cancers, has been discussed in detail. The effects of cinnamaldehydes on leukemia, hepatocellular carcinoma, and oral cancer have been summarized briefly. Copyright © 2016 John Wiley & Sons, Ltd.
肉桂醛及其衍生物是抗癌药物开发的候选药物，受到广泛关注。在这篇综述中，我们总结了最近的研究结果，详细说明了肉桂醛及其衍生物作为潜在抗癌药物候选物的积极和消极方面。此外，我们还描述了肉桂醛的体内药代动力学和代谢。肉桂醛的氧化和抗氧化特性对其在化疗中的潜在作用也进行了讨论。此外，还探讨了肉桂醛诱导癌细胞凋亡的机制。此外，还描述了肉桂醛对癌细胞侵袭和转移的调节作用的证据。最后，详细讨论了肉桂醛在治疗各种类型癌症（包括乳腺癌、前列腺癌和结肠癌）中的应用。简要总结了肉桂醛对白血病、肝癌和口腔癌的影响。版权所有 © 2016 年 John Wiley & Sons, Ltd.
