Mesropian Paul Der, Othersen Jennifer, Mason Darius, Wang Jeffrey, Asif Arif, Mathew Roy O
Division of Nephrology, Department of Medicine, Stratton Veterans Affairs Medical Center, Albany, New York, USA.
Division of Nephrology, Department of Medicine, William Jennings Bryan Dorn Veterans Affairs Medical Center, Columbia, South Carolina, USA.
Nephrology (Carlton). 2016 Sep;21(9):729-35. doi: 10.1111/nep.12751.
Community-acquired acute kidney injury (CA-AKI) has been found to be a common event in the population. Current incidence estimates are not available, but evaluations of severe elevations in serum creatinine indicate that incidence can be as high as 989 cases per million population in those older than 80 years. Data on risk factors are limited, but older age and higher comorbid illness burden, especially diabetes and cardiovascular disease, seem to be more common in patients who suffer CA-AKI. In addition to being more common than hospital-acquired AKI, the long-term sequelae of CA-AKI seem to be just as severe, including renal disease progression and mortality. Efforts to better understand the aetiology of CA-AKI and how ultimately to prevent the development of this condition will need to be taken. In the meantime, a concerted effort by general internists and nephrologists will be needed to prevent CA-AKI in the highest risk patients and thus limit the poor outcomes associated with this entity.
社区获得性急性肾损伤（CA-AKI）已被发现是人群中的常见事件。目前尚无发病率的估计数据，但血清肌酐严重升高的评估表明，80岁以上人群的发病率可达每百万人989例。关于危险因素的数据有限，但年龄较大和共病负担较高，尤其是糖尿病和心血管疾病，在患CA-AKI的患者中似乎更为常见。除了比医院获得性急性肾损伤更常见外，CA-AKI的长期后遗症似乎同样严重，包括肾病进展和死亡。需要努力更好地了解CA-AKI的病因以及最终如何预防这种疾病的发生。与此同时，普通内科医生和肾病学家需要共同努力，预防高危患者发生CA-AKI，从而限制与此相关的不良后果。
