Leong Jia-Li, Li Hui-Hua, Chan Ling-Ling, Tan Eng-King
National University of Singapore, Yong Loo Lin School of Medicine, Singapore, 119077, Singapore.
Singapore General Hospital, Health Services Research and Biostatistics Unit, Division of Research, Singapore, 169608, Singapore.
Sci Rep. 2016 Feb 19;6:21082. doi: 10.1038/srep21082.
The relationship between hypertension and hemifacial spasm (HFS) has been debated. Microvascular decompression surgery is effective in some HFS patients with uncontrolled hypertension. To address current gaps in knowledge, we conducted a meta-analysis of case-control studies that have examined the prevalence of hypertension in HFS patients compared to non-HFS controls. We also evaluated the implications and limitations of the pooled studies. We identified 62 studies from PubMed, The Cochrane Library, Web of Science and Scholar.google.com and six studies that fit our inclusion criteria were included. A random-effects model was used to derive the pooled estimate of the Odds Ratio. The data was plotted on a Forest plot. A pooled analysis involving 51585 subjects, 549 cases, 720 neurological controls and 50316 controls from the general population, showed that HFS patients had a higher chance of developing hypertension (OR = 1.72, 95% CI = (1.12, 2.31), p-value <0.001). The prevalence of hypertension was higher in HFS patients as compared to non-HFS patients. This meta-analysis highlights a positive correlation between hypertension and HFS. Blood pressure should be closely monitored during the follow-up of HFS patients. Preliminary links between ventrolateral medullary (VLM) compression and HFS should be further evaluated in future studies.
高血压与面肌痉挛（HFS）之间的关系一直存在争议。微血管减压手术对一些高血压控制不佳的HFS患者有效。为了填补当前知识空白，我们对病例对照研究进行了荟萃分析，这些研究比较了HFS患者与非HFS对照者中高血压的患病率。我们还评估了汇总研究的意义和局限性。我们从PubMed、Cochrane图书馆、科学网和Scholar.google.com中识别出62项研究，其中六项符合我们纳入标准的研究被纳入。采用随机效应模型得出优势比的汇总估计值。数据绘制在森林图上。一项涉及51585名受试者、549例病例、720名神经科对照者和50316名普通人群对照者的汇总分析表明，HFS患者患高血压的几率更高（OR = 1.72，95% CI =（1.12，2.31），p值<0.001）。与非HFS患者相比，HFS患者中高血压的患病率更高。这项荟萃分析突出了高血压与HFS之间的正相关关系。在HFS患者的随访过程中应密切监测血压。未来的研究应进一步评估延髓腹外侧（VLM）受压与HFS之间的初步联系。
