Tarı Mahmut, Ataç Ceyla, Ak Ayşın Kısabay, Ortan Pınar, Gökçay Figen, Çelebisoy Neşe
Department of Neurology, University of Health Sciences Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.
Department of Neurology, İzmir Celal Bayar Univesity Faculty of Medicine, Manisa, Turkey.
Acta Neurol Belg. 2025 Aug 8. doi: 10.1007/s13760-025-02868-y.
Hemifacial spasm (HFS) and blepharospasm (BS) are movement disorders involving the facial muscles. HFS is linked to facial nerve, nucleus irritation and BS to basal ganglia dysfunction causing hyperexcitability of brainstem interneurons. Cervical vestibular-evoked myogenic potential (cVEMP) responses demonstrate the saccullocollic reflex. This study aimed to evaluate saccullocollic pathways using the cVEMP test in HFS and BS patients with abnormal brainstem activity.
Our study was conducted between July 2022 and December 2023 at Movement Disorders Outpatient Clinic of Neurology Department, including 54 HFS and 32 BS patients and 50 healthy volunteers. Peak p13 and n23 latencies, peak-to-peak p13-n23 amplitudes, and amplitude asymmetry ratios (AAR) of the responses recorded from the sternocleidomastoid muscle ipsilateral to the stimulated ear was recorded and the results gathered from the patients were compared with the results of the healthy controls. Results of the affected and unaffected sides of the HFS patients were also compared.
There was no significant difference regarding age between patient and control groups. The female gender was higher in the BS group. No statistically significant differences were observed in terms of right and left p13 and n23 latencies and p13-n23 amplitude parameters in comparison of the patient groups and healthy controls. Comparison of the affected and unaffected sides of the HFS patients did not reveal a significant difference.
This study found no evidence of saccullocollic involvement in HFS and BS patients using the cVEMP test. It is important as a guiding study for future research.
半面痉挛（HFS）和眼睑痉挛（BS）是涉及面部肌肉的运动障碍。HFS与面神经、神经核刺激有关，而BS与基底神经节功能障碍有关，后者导致脑干中间神经元的过度兴奋。颈前庭诱发肌源性电位（cVEMP）反应可显示球囊-颈反射。本研究旨在使用cVEMP测试评估脑干活动异常的HFS和BS患者的球囊-颈通路。
我们的研究于2022年7月至2023年12月在神经内科运动障碍门诊进行，包括54例HFS患者、32例BS患者和50名健康志愿者。记录刺激耳同侧胸锁乳突肌的p13和n23峰潜伏期、p13-n23峰峰值振幅以及振幅不对称率（AAR），并将患者的结果与健康对照的结果进行比较。还比较了HFS患者患侧和未患侧的结果。
患者组和对照组之间在年龄方面无显著差异。BS组中女性比例较高。在患者组与健康对照的比较中，左右p13和n23潜伏期以及p13-n23振幅参数方面未观察到统计学上的显著差异。HFS患者患侧和未患侧的比较未显示出显著差异。
本研究未发现使用cVEMP测试的HFS和BS患者存在球囊-颈受累的证据。作为未来研究的指导性研究，这很重要。
