Xu Pengfei, Dai Shu, Wang Jing, Zhang Jun, Liu Jin, Wang Fang, Zhai Yonggong
Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Sci Rep. 2016 Feb 19;6:19659. doi: 10.1038/srep19659.
Western diets are typically high in fat and are associated with long-term complications such as obesity and hepatic steatosis. Because of the enjoyable taste of high-fat diets (HFDs), we are interested in determining how to decrease lipid absorption and enhance lipid excretion from the digestive tract after the consumption of eating fatty foods. Montmorillonite was initially characterized as a gastrointestinal mucosal barrier protective agent for the treatment of diarrhoea. Dietary lipid adsorbent- montmorillonite (DLA-M) was isolated and purified from Xinjiang montmorillonite clay via the water extraction method. Here, we show that DLA-M has an unexpected role in preventing obesity, hyperlipidaemia and hepatic steatosis in HFD-fed rats. Interestingly, combined application of polarized light microscopy and lipid staining analyses, showed that DLA-M crystals have dietary lipid-adsorbing ability in vitro and in vivo, which enhances lipid excretion via bowel movements. In summary, our results indicate that DLA-M prevent HFD-induced obesity. This novel dietary lipid-adsorbing agent can help prevent obesity and its comorbidities.
西方饮食通常脂肪含量高，并与肥胖和肝脂肪变性等长期并发症相关。由于高脂饮食（HFD）味道鲜美，我们有兴趣确定如何在食用高脂肪食物后减少脂质吸收并增强消化道的脂质排泄。蒙脱石最初被表征为用于治疗腹泻的胃肠道粘膜屏障保护剂。通过水提取法从新疆蒙脱石粘土中分离并纯化了膳食脂质吸附剂 - 蒙脱石（DLA-M）。在这里，我们表明DLA-M在预防HFD喂养的大鼠肥胖、高脂血症和肝脂肪变性方面具有意想不到的作用。有趣的是，偏振光显微镜和脂质染色分析的联合应用表明，DLA-M晶体在体外和体内具有膳食脂质吸附能力，可通过排便增强脂质排泄。总之，我们的结果表明DLA-M可预防HFD诱导的肥胖。这种新型膳食脂质吸附剂有助于预防肥胖及其合并症。
