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通过蒙脱土吸附-排泄轴重塑微生物组可预防肥胖相关代谢紊乱。

Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders.

机构信息

Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China.

Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China.

出版信息

EBioMedicine. 2017 Feb;16:251-261. doi: 10.1016/j.ebiom.2017.01.019. Epub 2017 Jan 18.

DOI:10.1016/j.ebiom.2017.01.019
PMID:28126594
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5474441/
Abstract

Obesity and its related metabolic disorders are closely correlated with gut dysbiosis. Montmorillonite is a common medicine used to treat diarrhea. We have previously found that dietary lipid adsorbent-montmorillonite (DLA-M) has an unexpected role in preventing obesity. The aim of this study was to further investigate whether DLA-M regulates intestinal absorption and gut microbiota to prevent obesity-related metabolic disorders. Here, we show that DLA-M absorbs free fatty acids (FFA) and endotoxins in vitro and in vivo. Moreover, the combination of fluorescent tracer technique and polarized light microscopy showed that DLA-M crystals immobilized BODIPY® FL C16 and FITC-LPS, respectively, in the digestive tract in situ. HFD-fed mice treated with DLA-M showed mild changes in the composition of the gut microbiota, particularly increases in short-chain fatty acids (SCFA)-producing Blautia bacteria and decreases in endotoxin-producing Desulfovibrio bacteria, these changes were positively correlated with obesity and inflammation. Our results indicated that DLA-M immobilizes FFA and endotoxins in the digestive tract via the adsorption-excretion axis and DLA-M may potentially be used as a prebiotic to prevent intestinal dysbiosis and obesity-associated metabolic disorders in obese individuals.

摘要

肥胖及其相关代谢紊乱与肠道菌群失调密切相关。蒙脱石是一种常用于治疗腹泻的常用药物。我们之前发现，膳食脂质吸附蒙脱石（DLA-M）在预防肥胖方面具有意想不到的作用。本研究旨在进一步探讨 DLA-M 是否通过调节肠道吸收和肠道微生物群来预防肥胖相关代谢紊乱。在这里，我们表明 DLA-M 在体外和体内吸收游离脂肪酸（FFA）和内毒素。此外，荧光示踪技术和偏光显微镜的组合表明，DLA-M 晶体分别在原位固定 BODIPY® FL C16 和 FITC-LPS 在消化道中。用 DLA-M 治疗的 HFD 喂养的小鼠肠道微生物群的组成发生了轻微变化，特别是产生短链脂肪酸（SCFA）的布劳氏菌增加，产生内毒素的脱硫弧菌减少，这些变化与肥胖和炎症呈正相关。我们的结果表明，DLA-M 通过吸附-排泄轴将 FFA 和内毒素固定在消化道中，DLA-M 可能可用作预防肠道菌群失调和肥胖相关代谢紊乱的益生元。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/ea52172416ca/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/d5d8fc8a799e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/2b0a188532ab/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/b317d8868a85/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/46b0aaa8f0d6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/2828cb5786c4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/874467ccddb9/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/ea52172416ca/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/d5d8fc8a799e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/2b0a188532ab/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/b317d8868a85/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/46b0aaa8f0d6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/2828cb5786c4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/874467ccddb9/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7601/5474441/ea52172416ca/gr7.jpg

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