De-Paula Vanessa J, Kerr Daniel S, Scola Gustavo, Gattaz Wagner F, Forlenza Orestes V
Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil.
Curr Alzheimer Res. 2016;13(8):848-52. doi: 10.2174/1567205013666160219112612.
Lithium is associated with various effects on immune functions, some of which are still poorly understood. The roles of many cytokines have been characterized in a variety of neurodevelopmental processes including neurogenesis, neuronal and glial cell migration, proliferation, differentiation, synaptic maturation and synaptic pruning. This work aims to evaluate the effects of different doses of lithium (0.02; 0.2 and 2mM) on the secretion of cytokines in co-cultures of cortical and hippocampal neurons with glial cells. Our results indicate that chronic treatment with lithium chloride at subtherapeutic concentrations are able to modify the secretion of pro- and anti-inflammatory interleukins in co-cultures of cortical and hippocampal neurons with glial cells.
锂与免疫功能的多种效应相关，其中一些效应仍未被充分理解。许多细胞因子在包括神经发生、神经元和神经胶质细胞迁移、增殖、分化、突触成熟和突触修剪在内的各种神经发育过程中的作用已得到表征。这项工作旨在评估不同剂量的锂（0.02；0.2和2 mM）对皮质和海马神经元与神经胶质细胞共培养物中细胞因子分泌的影响。我们的结果表明，亚治疗浓度的氯化锂慢性处理能够改变皮质和海马神经元与神经胶质细胞共培养物中促炎和抗炎白细胞介素的分泌。
