Bajaj Jagminder K, Salwan Poonam, Salwan Shalini
Professor and Head, Department of Pharmacology, PIMS , Jalandhar, India .
Assistant Professor, Department of Pharmacology, SGT Medical College and Hospital , Gurgaon, India .
J Clin Diagn Res. 2016 Jan;10(1):FE01-3. doi: 10.7860/JCDR/2016/15195.7092. Epub 2016 Jan 1.
About 300 million people across the world suffer from thyroid gland dysfunction. Environmental factors play an important role in causation of autoimmune thyroid diseases in susceptible individuals. Genetics contributes to 70% of the risk. In order to reduce the risk, we need to understand the association of environmental agents with thyroid dysfunction. These factors are especially relevant for those at increased risk due to positive family history. The ideal study to see the impact of a thyroid toxicant consists of directly measuring the degree of exposure to toxicant in an individual with his thyroid status. Knowledge of various factors influencing thyroid dysfunction can help in interpreting the results of such studies in a better way. This article is an attempt to highlight the various possible toxicants affecting thyroid function so that adequate measures can be undertaken to control excessive exposure in future to reduce the prevalence of thyroid disorders.
全球约有3亿人患有甲状腺功能障碍。环境因素在易感个体自身免疫性甲状腺疾病的病因中起着重要作用。遗传学导致了70%的患病风险。为了降低风险，我们需要了解环境因素与甲状腺功能障碍之间的关联。这些因素对于那些因家族史呈阳性而患病风险增加的人尤为重要。观察甲状腺毒物影响的理想研究包括直接测量个体接触毒物的程度及其甲状腺状态。了解影响甲状腺功能障碍的各种因素有助于更好地解释此类研究的结果。本文旨在强调各种可能影响甲状腺功能的毒物，以便未来能够采取适当措施控制过度接触，从而降低甲状腺疾病的患病率。
