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一项基于医院的关于2型糖尿病患者糖化血红蛋白与糖尿病视网膜病变严重程度之间关联的知晓情况的研究。

A Hospital Based Study Regarding Awareness of Association Between Glycosylated Haemoglobin and Severity of Diabetic Retinopathy in Type 2 Diabetic Individuals.

作者信息

Prabhu Mridula, Kakhandaki Anupama, Chandra K R Pravin, Dinesh M B

机构信息

Associate Professor, Department of Ophthalmology, S D M College of Medical Sciences and Hospital , Sattur, Dharwad, India .

Professor, Department of Ophthalmology, S D M College of Medical Sciences and Hospital , Sattur, Dharwad, India .

出版信息

J Clin Diagn Res. 2016 Jan;10(1):NC01-4. doi: 10.7860/JCDR/2016/15834.7014. Epub 2016 Jan 1.

Abstract

INTRODUCTION

Diabetic retinopathy is one of the most common microvascular complications seen in diabetic patients after a long term of uncontrolled glycaemic status as assessed by glycosylated Haemoglobin A (HbA1c). Hence awareness of glycaemic control is necessary to prevent vision threatening complications.

AIM

To assess the awareness regarding association between glycosylated Haemoglobin (HbA1c) and diabetic retinopathy among diabetic patients and to assess the impact of lack of this knowledge on the severity of diabetic retinopathy (DR).

MATERIALS AND METHODS

This hospital based cross-sectional study was conducted in the ophthalmology OPD on 200 adult diabetic patients, between November 2012 and January 2013, who were assessed for their knowledge regarding association between HbA1c and its impact on the progress of DR. The study was done with the help of a semi structured questionnaire which included demographic details, literacy levels, diabetic status and awareness of HbA1c.

STATISTICS USED

Cochran Armitage test for trend, Fisher Exact test, chi-square for trend and Student's t test.

RESULTS

Among the 200 diabetic individuals attending our OPD, 180 (90%) were aware of the importance of blood sugar levels and its fluctuation in type 2 diabetes. Only 23 (11.5%) were aware of HbA1c whereas 10 (5%) misinterpreted it as levels of haemoglobin, 3 (1.5%) did not completely comprehend. About 164 (82%) patients were not aware of the significance or the terminology of HbA1c. Out of the 200 patients, 58 patients showed presence of some grade of DR. Amongst these 58 patients, 7(12.1%) were aware of HbA1c and all the11 patients with clinically significant macular oedema (CSME) were aware of the risk factors of elevated blood sugar levels but ignorant of HbA1c. Among the remaining 142 individuals who showed no signs of DR, 16 (27.5%) were aware of and comprehended the role of HbA1c.

CONCLUSION

Our study highlights the gross ignorance of role of HbA1c in the progress of DR among diabetic individuals. It is a known fact that the risk of DR reduces by 35% for every 1% reduction in HbA1c. Hence a strict control of blood sugar level with regular monitoring of HbA1c can help diabetic individuals in prevention of progress of DR, thus preventing severe vision loss.

摘要

引言

糖尿病视网膜病变是糖尿病患者在长期糖化血红蛋白A(HbA1c)评估显示血糖控制不佳后最常见的微血管并发症之一。因此,了解血糖控制对于预防威胁视力的并发症至关重要。

目的

评估糖尿病患者对糖化血红蛋白(HbA1c)与糖尿病视网膜病变之间关联的认知情况,并评估缺乏该知识对糖尿病视网膜病变(DR)严重程度的影响。

材料与方法

这项基于医院的横断面研究于2012年11月至2013年1月在眼科门诊对200名成年糖尿病患者进行,评估他们对HbA1c之间关联及其对DR进展影响的了解情况。该研究借助半结构化问卷进行,问卷包括人口统计学细节、识字水平、糖尿病状况和对HbA1c的认知。

使用的统计方法

趋势的 Cochr an Armitage检验、Fisher精确检验、趋势的卡方检验和学生t检验。

结果

在我们门诊就诊的200名糖尿病患者中,180名(90%)知晓血糖水平及其波动在2型糖尿病中的重要性。只有23名(11.5%)知晓HbA1c,而10名(5%)将其误解为血红蛋白水平,3名(1.5%)没有完全理解。约164名(82%)患者不知道HbA1c的意义或术语。在200名患者中,58名患者显示存在某种程度的DR。在这58名患者中,7名(12.1%)知晓HbA1c,所有11名患有临床显著性黄斑水肿(CSME)的患者知晓血糖水平升高的危险因素,但对HbA1c一无所知。在其余142名未显示DR迹象的个体中,16名(27.5%)知晓并理解HbA1c的作用。

结论

我们的研究突出了糖尿病个体对HbA1c在DR进展中作用的严重无知。众所周知,HbA1c每降低1%,DR风险降低35%。因此,通过定期监测HbA1c严格控制血糖水平可帮助糖尿病个体预防DR进展,从而防止严重视力丧失。

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