Badam Raj Kumar, Suram Jyotsna, Babu Dara Balaji Gandhi, Waghray Shefali, Marshal Rahul, Bontha Sharath Chandra, Lavanya Reddy, Kanth Sudheer
Reader, Department of Oral Medicine & Radiology, Panineeya Mahavidhyalaya College of Dental Sciences , Hyderabad, India .
Senior Lecturer, Department of Oral Medicine & Radiology, Shadan Dental College , Hyderabad, India .
J Clin Diagn Res. 2016 Jan;10(1):ZC60-2. doi: 10.7860/JCDR/2016/16091.7121. Epub 2016 Jan 1.
Thyroid carcinoma represents less than 1% of all cancers. The first line of treatment for thyroid cancer is partial/total thyroidectomy. High-dose Iodine(131) therapy using Iodine radioisotopes is commonly used in patients with well differentiated thyroid carcinoma after total thyroidectomy. In this process, the non-thyroidal tissues, such as, salivary gland, stomach and breast tissues also take up radioactive iodine. Salivary gland scintigraphy is widely accepted as a sensitive and valid method for evaluation of salivary gland dysfunction after Radioactive Iodine(131) Therapy (RIT).
To assess and compare the salivary flow rates, relative uptake and ejection fractions in parotid and submandibular glands just before and one month after Iodine(131) therapy.
The study was conducted on 24 patients diagnosed with well differentiated thyroid carcinoma who underwent partial/total thyroidectomy and were due for radioactive iodine therapy. These patients were divided into two groups based on the lesion based dosimetry (Group A: 60-100Gy; Group B: 100-150Gy). Salivary gland assessment was done by salivary gland scintigraphy before and after RIT.
The data collected was tabulated and statistically analysed using SPSS software version16 using paired t-test and individual sample t-test.
A statistically significant difference in the uptake percent and ejection fraction percent in the parotid and submandibular glands before RIT and one month after RIT was observed in the study.
We inferred from the study that there was an overall decrease in uptake percent and ejection fraction percent one month post RIT in both parotid and submandibular glands. Also, a statistically significant difference was noted in the uptake and ejection fraction percent between Group A and Group B concluding the fact that the damage is dose related.
甲状腺癌在所有癌症中占比不到1%。甲状腺癌的一线治疗方法是部分/全甲状腺切除术。全甲状腺切除术后，高剂量碘（131）疗法使用碘放射性同位素常用于分化型甲状腺癌患者。在此过程中，非甲状腺组织，如唾液腺、胃和乳腺组织也会摄取放射性碘。唾液腺闪烁扫描被广泛认为是评估放射性碘（131）治疗（RIT）后唾液腺功能障碍的一种敏感且有效的方法。
评估并比较碘（131）治疗前及治疗后1个月腮腺和颌下腺的唾液流速、相对摄取率和排出分数。
本研究对24例诊断为分化型甲状腺癌且接受了部分/全甲状腺切除术并即将接受放射性碘治疗的患者进行。根据基于病灶的剂量测定将这些患者分为两组（A组：60 - 100Gy；B组：100 - 150Gy）。在RIT前后通过唾液腺闪烁扫描对唾液腺进行评估。
收集的数据制成表格，并使用SPSS软件版本16进行统计分析，采用配对t检验和单样本t检验。
本研究观察到RIT前及RIT后1个月腮腺和颌下腺的摄取百分比和排出分数百分比存在统计学显著差异。
我们从该研究中推断，RIT后1个月腮腺和颌下腺的摄取百分比和排出分数百分比总体下降。此外，A组和B组之间在摄取和排出分数百分比方面存在统计学显著差异，这表明损伤与剂量相关。
