Cazzola Mario, Rogliani Paola, Ora Josuel, Matera Maria Gabriella
a Department of Systems Medicine , University of Rome Tor Vergata , Rome , Italy.
b Department of Experimental Medicine , Second University of Naples , Naples , Italy.
Expert Opin Pharmacother. 2016;17(7):977-88. doi: 10.1517/14656566.2016.1155555. Epub 2016 Mar 21.
The appropriate drug management of COPD is still based on the use of bronchodilators, possibly associated with an anti-inflammatory agent. However, there are still fundamental questions that require clarification to optimise their use and major unmet clinical needs that must be addressed.
The advances obtained with the pharmacological options currently consolidated and the different approaches that are often used in an attempt to respond to unmet therapeutic needs are reviewed Expert opinion: In view of the unsatisfactory status of current treatments for COPD, there is an urgent need for alternative and more effective therapeutic approaches that will help to relieve patient symptoms and affect the natural course of COPD, inhibiting chronic inflammation and reversing the disease process or preventing its progression. However, new pharmacologic options have proved difficult to develop. Therefore, it is mandatory to optimize the use of the treatment options at our disposal. However, there are still fundamental questions regarding their use, including the step-up and step-down pharmacological approach, that require clarification to optimise the use of these drugs. It is likely that phenotyping COPD patients would help in identifying the right treatment for each COPD patient and improve the effectiveness of therapies.
慢性阻塞性肺疾病（COPD）的合理药物治疗仍基于使用支气管扩张剂，可能还会联合使用抗炎药。然而，仍有一些基本问题需要澄清以优化其使用，并且存在一些必须解决的重大未满足的临床需求。
回顾了目前已巩固的药物治疗方法所取得的进展以及为满足未满足的治疗需求而经常采用的不同方法。
鉴于目前COPD治疗效果不尽人意，迫切需要替代性的、更有效的治疗方法，以帮助缓解患者症状并影响COPD的自然病程，抑制慢性炎症并逆转疾病进程或防止其进展。然而，事实证明开发新的药物选择很困难。因此，必须优化我们现有治疗方案的使用。然而，关于这些药物的使用仍有一些基本问题，包括逐步增加和逐步减少用药的药理学方法，需要澄清以优化这些药物的使用。对COPD患者进行表型分析可能有助于为每位COPD患者确定合适的治疗方法并提高治疗效果。
