• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

神经肿瘤学生物技术行业进展报告。

Neuro-oncology biotech industry progress report.

作者信息

Chakraborty Shamik, Bodhinayake Imithri, Chiluwal Amrit, Langer David J, Ruggieri Rosamaria, Symons Marc, Boockvar John A

机构信息

Brain Tumor Biotech Center, Feinstein Institute for Medical Research, Hofstra Northwell School of Medicine, Manhasset, NY, USA.

Department of Neurological Surgery, Hofstra Northwell School of Medicine, Manhasset, NY, USA.

出版信息

J Neurooncol. 2016 May;128(1):175-182. doi: 10.1007/s11060-016-2087-z. Epub 2016 Feb 20.

DOI:10.1007/s11060-016-2087-z
PMID:26897014
Abstract

The Brain Tumor Biotech Center at the Feinstein Institute for Medical Research, in collaboration with Voices Against Brain Cancer hosted The Brain Tumor Biotech Summit at in New York City in June 2015. The focus was once again on fostering collaboration between neuro-oncologist, neurosurgeons, scientists, leaders from biotechnology and pharmaceutical industries, and members of the financial community. The summit highlighted the recent advances in the treatment of brain tumor, and specifically focused on targeting of stem cells and EGFR, use of prophage and immunostimulatory vaccines, retroviral vectors for drug delivery, biologic prodrug, Cesium brachytherapy, and use of electric field to disrupt tumor cell proliferation. This article summarizes the current progress in brain tumor research as presented at 2015 The Brain Tumor Biotech Summit.

摘要

2015年6月,费因斯坦医学研究所的脑肿瘤生物技术中心与“抗击脑癌之声”合作,在纽约市举办了脑肿瘤生物技术峰会。会议重点再次放在促进神经肿瘤学家、神经外科医生、科学家、生物技术和制药行业领袖以及金融界成员之间的合作上。峰会突出了脑肿瘤治疗方面的最新进展,特别聚焦于干细胞和表皮生长因子受体(EGFR)的靶向治疗、噬菌体和免疫刺激疫苗的应用、用于药物递送的逆转录病毒载体、生物前体药物、铯近距离治疗以及利用电场干扰肿瘤细胞增殖。本文总结了在2015年脑肿瘤生物技术峰会上展示的脑肿瘤研究的当前进展。

相似文献

1
Neuro-oncology biotech industry progress report.神经肿瘤学生物技术行业进展报告。
J Neurooncol. 2016 May;128(1):175-182. doi: 10.1007/s11060-016-2087-z. Epub 2016 Feb 20.
2
Industry progress report on neuro-oncology: Biotech update 2013.神经肿瘤学行业进展报告:2013 年生物技术更新。
J Neurooncol. 2013 Nov;115(2):311-6. doi: 10.1007/s11060-013-1222-3. Epub 2013 Aug 16.
3
Industry progress report on neuro-oncology: a biotech update.神经肿瘤学行业进展报告:生物技术更新。
J Neurooncol. 2013 Apr;112(2):315-21. doi: 10.1007/s11060-012-1036-8. Epub 2013 Feb 20.
4
Update on glioma biotechnology.神经胶质瘤生物技术的最新进展
Clin Neurol Neurosurg. 2020 Aug;195:106075. doi: 10.1016/j.clineuro.2020.106075. Epub 2020 Jul 7.
5
Financial risk of the biotech industry versus the pharmaceutical industry.生物技术行业与制药行业的财务风险。
Appl Health Econ Health Policy. 2009;7(3):155-65. doi: 10.1007/BF03256149.
6
Financial Times Global Pharmaceutical & Biotechnology Conference 2009.2009年英国《金融时报》全球制药与生物技术大会
IDrugs. 2010 Jan;13(1):26-9.
7
Infrastructure, biotech top African science summit agenda.基础设施、生物技术位列非洲科学峰会议程之首。
Nat Med. 2007 Mar;13(3):228. doi: 10.1038/nm0307-228a. Epub 2007 Feb 28.
8
Perspective: Biotech funding trends: Insights from entrepreneurs and investors.观点:生物技术融资趋势:来自企业家和投资者的见解。
Biotechnol J. 2009 Aug;4(8):1102-5. doi: 10.1002/biot.200900147.
9
Business Ethics 101 for the biotech industry.生物技术行业的商业伦理基础课程。
BioDrugs. 2004;18(2):71-7. doi: 10.2165/00063030-200418020-00001.
10
Importance of dose intensity in neuro-oncology clinical trials: summary report of the Sixth Annual Meeting of the Blood-Brain Barrier Disruption Consortium.剂量强度在神经肿瘤学临床试验中的重要性:血脑屏障破坏联盟第六届年会总结报告
Neuro Oncol. 2001 Jan;3(1):46-54. doi: 10.1093/neuonc/3.1.46.

引用本文的文献

1
Glioblastoma Treatments: An Account of Recent Industrial Developments.胶质母细胞瘤的治疗:近期产业发展综述
Front Pharmacol. 2018 Sep 13;9:879. doi: 10.3389/fphar.2018.00879. eCollection 2018.

本文引用的文献

1
Human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer: how the latest results are improving therapeutic options.人表皮生长因子受体2阳性(HER2+)转移性乳腺癌:最新研究结果如何改善治疗选择
Ther Adv Med Oncol. 2015 Nov;7(6):321-39. doi: 10.1177/1758834015599389.
2
TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo.TIC10/ONC201在体外和体内通过抑制Mcl-1及其结合伴侣,与胶质母细胞瘤中的Bcl-2/Bcl-xL抑制协同作用。
Oncotarget. 2015 Nov 3;6(34):36456-71. doi: 10.18632/oncotarget.5505.
3
Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types.
逆转录病毒复制载体递送胞嘧啶脱氨酶,导致多种人类癌症类型中靶向5-氟尿嘧啶介导的细胞毒性。
Hum Gene Ther Methods. 2016 Feb;27(1):17-31. doi: 10.1089/hgtb.2015.106. Epub 2015 Dec 1.
4
An Update on the Role of Immunotherapy and Vaccine Strategies for Primary Brain Tumors.原发性脑肿瘤免疫治疗和疫苗策略作用的最新进展
Curr Treat Options Oncol. 2015 Nov;16(11):54. doi: 10.1007/s11864-015-0371-3.
5
Ligand-Independent EGFR Signaling.非配体依赖的表皮生长因子受体信号传导
Cancer Res. 2015 Sep 1;75(17):3436-41. doi: 10.1158/0008-5472.CAN-15-0989. Epub 2015 Aug 17.
6
Outcomes of the ACT III Study: Rindopepimut (CDX-110) Therapy for Glioblastoma.ACT III研究结果:rindopepimut(CDX - 110)治疗胶质母细胞瘤
Neurosurgery. 2015 Jun;76(6):N17. doi: 10.1227/01.neu.0000465855.63458.0c.
7
Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway.可诱导TRAIL的化合物的鉴定突出了小分子ONC201/TIC10作为一种激活TRAIL途径的独特抗癌剂。
Mol Cancer. 2015 May 1;14:99. doi: 10.1186/s12943-015-0346-9.
8
TIC10/ONC201: a bend in the road to clinical development.TIC10/ONC201:临床开发道路上的一个转折点。
Oncoscience. 2015 Feb 20;2(2):75-6. doi: 10.18632/oncoscience.133. eCollection 2015.
9
Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner.小分子 ONC201/TIC10 通过 Akt/Foxo3a/TRAIL 依赖的方式靶向化疗耐药结直肠肿瘤干细胞。
Cancer Res. 2015 Apr 1;75(7):1423-32. doi: 10.1158/0008-5472.CAN-13-3451. Epub 2015 Feb 20.
10
Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma.目前针对胶质母细胞瘤中 EGFR 和 EGFRvIII 的治疗进展。
Front Oncol. 2015 Jan 29;5:5. doi: 10.3389/fonc.2015.00005. eCollection 2015.