Price Nathan L, Fernández-Hernando Carlos
Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine and Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine and Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2104-2110. doi: 10.1016/j.bbalip.2016.02.010. Epub 2016 Feb 16.
Obesity and metabolic disorders are a major health concern in all developed countries and a primary focus of current medical research is to improve our understanding treatment of metabolic diseases. One avenue of research that has attracted a great deal of recent interest focuses upon understanding the role of miRNAs in the development of metabolic diseases. miRNAs have been shown to be dysregulated in a number of different tissues under conditions of obesity and insulin resistance, and have been demonstrated to be important regulators of a number of critical metabolic functions, including insulin secretion in the pancreas, lipid and glucose metabolism in the liver, and nutrient signaling in the hypothalamus. In this review we will focus on the important role of miRNAs in regulating the differentiation and function of white and brown adipose tissue and the potential importance of this for maintaining metabolic function and treating metabolic diseases. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.
肥胖和代谢紊乱是所有发达国家主要的健康问题，当前医学研究的一个主要重点是增进我们对代谢疾病治疗的理解。最近引起大量关注的一个研究方向聚焦于了解微小RNA（miRNA）在代谢疾病发展中的作用。研究表明，在肥胖和胰岛素抵抗条件下，多种不同组织中的miRNA表达失调，并且已证明其是许多关键代谢功能的重要调节因子，包括胰腺中的胰岛素分泌、肝脏中的脂质和葡萄糖代谢以及下丘脑中的营养信号传导。在本综述中，我们将重点关注miRNA在调节白色和棕色脂肪组织的分化和功能方面的重要作用，以及这对于维持代谢功能和治疗代谢疾病的潜在重要性。本文是由卡洛斯·费尔南德斯 - 埃尔南多（Carlos Fernández-Hernando）和亚贾伊拉·苏亚雷斯（Yajaira Suárez）编辑的名为《微小RNA与脂质/能量代谢及相关疾病》特刊的一部分。
