Araldi Elisa, Suárez Yajaira
Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA.
Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA.
Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2094-2103. doi: 10.1016/j.bbalip.2016.01.013. Epub 2016 Jan 26.
Endothelial cells (ECs) provide nutrients and oxygen essential for tissue homeostasis. Metabolic imbalances and other environmental stimuli, like cytokines or low shear stress, trigger endothelial inflammation, increase permeability, compromise vascular tone, promote cell proliferation, and ultimately cause cell death. These factors contribute to EC dysfunction, which is crucial in the development of cardiometabolic diseases. microRNAs (miRNAs) are small non-coding RNAs that have important functions in the regulation of ECs. In the present review, we discuss the role of miRNAs in various aspects of EC pathology in cardiometabolic diseases like atherosclerosis, type 2 diabetes, obesity, and the metabolic syndrome, and in complication of those pathologies, like ischemia. We also discuss the potential therapeutic applications of miRNAs in promoting angiogenesis and neovascularization in tissues where the endothelium is damaged in different cardiometabolic diseases. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.
内皮细胞（ECs）为组织稳态提供必需的营养物质和氧气。代谢失衡及其他环境刺激因素，如细胞因子或低剪切应力，会引发内皮炎症，增加通透性，损害血管张力，促进细胞增殖，并最终导致细胞死亡。这些因素会导致内皮细胞功能障碍，而这在心脏代谢疾病的发展过程中至关重要。微小RNA（miRNAs）是一类小的非编码RNA，在调节内皮细胞方面具有重要功能。在本综述中，我们讨论了miRNAs在动脉粥样硬化、2型糖尿病、肥胖症和代谢综合征等心脏代谢疾病的内皮细胞病理学各个方面的作用，以及在这些疾病并发症（如缺血）中的作用。我们还讨论了miRNAs在促进不同心脏代谢疾病中内皮受损组织的血管生成和新生血管形成方面的潜在治疗应用。本文是由卡洛斯·费尔南德斯 - 埃尔南多和亚贾伊拉·苏亚雷斯编辑的名为《微小RNA与脂质/能量代谢及相关疾病》特刊的一部分。
