Jeon Tae-Il, Osborne Timothy F
Department of Animal Science, Chonnam National University, Gwangju 61186, South Korea.
Integrative Metabolism Program, Sanford.Burnham.Prebys Medical Discovery Institute, Orlando, FL, United States.
Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2041-2046. doi: 10.1016/j.bbalip.2016.01.005. Epub 2016 Jan 15.
MicroRNAs (miRNAs) have recently emerged as a novel class of epigenetic regulators of gene expression. They are systemically involved in the control of lipid metabolism through a complex interactive mechanism that involves gene regulatory networks. Hence, they can contribute to defective lipid metabolism and metabolic diseases. Here, we review recent advances in the roles of lipid-sensing transcription factors in regulating miRNA gene networks, as well as miRNA expression and function in the regulation of cholesterol metabolism. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernández-Hernando and Yajaira Suárez.
微小RNA（miRNA）最近作为一类新型的基因表达表观遗传调节因子出现。它们通过涉及基因调控网络的复杂相互作用机制，系统性地参与脂质代谢的控制。因此，它们可能导致脂质代谢缺陷和代谢性疾病。在这里，我们综述了脂质感应转录因子在调节miRNA基因网络中的作用，以及miRNA在胆固醇代谢调节中的表达和功能方面的最新进展。本文是由卡洛斯·费尔南德斯 - 埃尔南多和亚贾伊拉·苏亚雷斯编辑的名为《微小RNA与脂质/能量代谢及相关疾病》特刊的一部分。
