用于免疫测定的5α-雄甾烷-3α,17β-二醇17-O-葡萄糖醛酸组胺基缀合物的合成。
Synthesis of 5α-androstane-3α,17β-diol 17-O-glucuronide histaminyl conjugate for immunoassays.
作者信息
Vinš Petr, Černý Ivan, Mikšátková Petra, Drašar Pavel
机构信息
Department of Chemistry of Natural Products, University of Chemistry and Technology, Technická 5, CZ 166 28 Praha 6, Czech Republic.
Department of Chemistry of Natural Products, University of Chemistry and Technology, Technická 5, CZ 166 28 Praha 6, Czech Republic.
出版信息
Steroids. 2016 May;109:56-9. doi: 10.1016/j.steroids.2016.02.011. Epub 2016 Feb 18.
Simple method of preparation of 5α-androstane-3α,17β-diol 17-O-glucuronide N-histaminyl amide was developed for the construction of immunoanalytical kit. Improved method of glucuronide derivative synthesis was used, followed by hydroxybenzotriazole-dicyclohexylcarbodiimide coupling with histamine.
为构建免疫分析试剂盒，开发了5α-雄甾烷-3α,17β-二醇17-O-葡萄糖醛酸苷N-组胺基酰胺的简易制备方法。采用了改进的葡萄糖醛酸苷衍生物合成方法，随后通过羟基苯并三唑-二环己基碳二亚胺与组胺偶联。
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