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用于放射免疫分析的新型甾体半抗原的合成。第三部分。15β-羧乙基巯基甾体-牛血清白蛋白缀合物。用于5α-二氢睾酮、5α-雄甾烷-3β,17β-二醇和5α-雄甾烷-3α,17β-二醇放射免疫分析的特异性抗血清。

Synthesis of new steroid haptens for radioimmunoassay. Part III. 15beta-Carboxyethylmercaptosteroid-bovine serum albumin conjugates. Specific antisera for radioimmunoassay of 5alpha-dihydrotestosterone, 5alpha-androstane-3beta, 17beta-diol and 5alpha-androstane-3alpha, 17beta-diol.

作者信息

Rao P N, Khan A H, Moore P H

出版信息

Steroids. 1977 Feb;29(2):171-84. doi: 10.1016/0039-128x(77)90037-x.

DOI:10.1016/0039-128x(77)90037-x
PMID:841620
Abstract

The syntheses of 15beta-carboxyethylmercapto-5alpha-dihydrotestosterone, 15beta-carbosyethylmercapto-5alpha-androstane-3beta, 17beta-diol and 15beta-carboxyethylmercapto-5alpha-androstane-3alpha, 17beta-diol and the preparation of their bovine serum albumin (BSA) conjugates are described. These conjugates were employed for the generation of specific antisera suitable for radioimmunoassay (RIA) of 5alpha-dihydrotestosterone (5alpha-DHT), 5alpha-androstane-3beta, 17beta-diol (3beta-diol) and 5alpha-androstane-3alpha, 17beta-diol (3alpha-diol).

摘要

描述了15β-羧乙基巯基-5α-二氢睾酮、15β-羧乙基巯基-5α-雄甾烷-3β,17β-二醇和15β-羧乙基巯基-5α-雄甾烷-3α,17β-二醇的合成及其牛血清白蛋白（BSA）缀合物的制备。这些缀合物用于产生适用于5α-二氢睾酮（5α-DHT）、5α-雄甾烷-3β,17β-二醇（3β-二醇）和5α-雄甾烷-3α,17β-二醇（3α-二醇）放射免疫分析（RIA）的特异性抗血清。

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1
Synthesis of new steroid haptens for radioimmunoassay. Part III. 15beta-Carboxyethylmercaptosteroid-bovine serum albumin conjugates. Specific antisera for radioimmunoassay of 5alpha-dihydrotestosterone, 5alpha-androstane-3beta, 17beta-diol and 5alpha-androstane-3alpha, 17beta-diol.用于放射免疫分析的新型甾体半抗原的合成。第三部分。15β-羧乙基巯基甾体-牛血清白蛋白缀合物。用于5α-二氢睾酮、5α-雄甾烷-3β,17β-二醇和5α-雄甾烷-3α,17β-二醇放射免疫分析的特异性抗血清。
Steroids. 1977 Feb;29(2):171-84. doi: 10.1016/0039-128x(77)90037-x.
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Immunization against 5alpha-androstane-3alpha,17beta-diol affects ovarian folliculogenesis in Merino ewes.针对5α-雄甾烷-3α,17β-二醇的免疫接种会影响美利奴母羊的卵泡发生。
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