在日本分离出的携带Cyp51A TR46/Y121F/T289A的多唑耐药烟曲霉。
Multi-azole resistant Aspergillus fumigatus harboring Cyp51A TR46/Y121F/T289A isolated in Japan.
作者信息
Hagiwara Daisuke, Takahashi Hiroki, Fujimoto Masanori, Sugahara Mai, Misawa Yoshiki, Gonoi Tohru, Itoyama Satoru, Watanabe Akira, Kamei Katsuhiko
机构信息
Division of Clinical Research, Medical Mycology Research Center, Chiba University, Japan.
Division of Bio-resources, Medical Mycology Research Center, Chiba University, Japan.
出版信息
J Infect Chemother. 2016 Aug;22(8):577-9. doi: 10.1016/j.jiac.2016.01.015. Epub 2016 Feb 16.
Multi-azole resistant Aspergillus fumigatus carrying TR46/Y121F/T289A was isolated from a patient in Japan in Dec 2013. This strain grouped into the same clade of the ones which were clinically isolated in France and Germany. A. fumigatus harboring this mutation could be rapidly diffused outside the Eurasian continent.
2013年12月，在日本一名患者身上分离出携带TR46/Y121F/T289A的多重唑类耐药烟曲霉。该菌株与在法国和德国临床分离出的菌株属于同一进化枝。携带这种突变的烟曲霉可能会迅速扩散到欧亚大陆以外。
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