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First isolation of the pan-azole-resistant Aspergillus fumigatus cyp51A TR46/Y121F/T289A mutant in a UK patient.

作者信息

Moore Caroline B, Novak-Frazer Lily, Muldoon Eavan, Dunn Kenneth W, Masania Rikesh, Richardson Malcolm D, Rautemaa-Richardson Riina

机构信息

Mycology Reference Centre Manchester, University Hospital of South Manchester, Manchester, UK; National Aspergillosis Centre, University Hospital of South Manchester, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Mycology Reference Centre Manchester, University Hospital of South Manchester, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

出版信息

Int J Antimicrob Agents. 2017 Apr;49(4):512-514. doi: 10.1016/j.ijantimicag.2017.01.004. Epub 2017 Feb 9.

DOI:10.1016/j.ijantimicag.2017.01.004
PMID:28193463
Abstract
摘要

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First isolation of the pan-azole-resistant Aspergillus fumigatus cyp51A TR46/Y121F/T289A mutant in a UK patient.在一名英国患者中首次分离出泛唑耐药烟曲霉cyp51A TR46/Y121F/T289A突变体。
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引用本文的文献

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J Antimicrob Chemother. 2022 Jul 28;77(8):2053-2073. doi: 10.1093/jac/dkac161.
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Evidence for the agricultural origin of resistance to multiple antimicrobials in Aspergillus fumigatus, a fungal pathogen of humans.证据表明，人类病原体烟曲霉对多种抗生素的耐药性起源于农业。
G3 (Bethesda). 2022 Feb 4;12(2). doi: 10.1093/g3journal/jkab427.
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and aspergillosis: From basics to clinics.
以及曲霉病：从基础到临床
Stud Mycol. 2021 May 10;100:100115. doi: 10.1016/j.simyco.2021.100115. eCollection 2021 Sep.
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Deciphering Aspergillus fumigatus cyp51A-mediated triazole resistance by pyrosequencing of respiratory specimens.通过呼吸样本的焦磷酸测序破译烟曲霉 Cyp51A 介导的唑类耐药性。
J Antimicrob Chemother. 2020 Dec 1;75(12):3501-3509. doi: 10.1093/jac/dkaa357.
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A 23 bp Promoter Deletion Associated With Voriconazole Resistance in Clinical and Environmental Isolates of .与临床和环境分离株中伏立康唑耐药性相关的23碱基对启动子缺失 。 （原文结尾处的“.”表述不完整，推测可能是某种真菌等微生物，但由于信息不足无法准确补充完整）
Front Microbiol. 2020 Mar 31;11:272. doi: 10.3389/fmicb.2020.00272. eCollection 2020.
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